Booster dose of BNT162b2 in a CoronaVac primary vaccination protocol improves neutralization of SARS-CoV-2 Omicron variant

The emergence of the new SARS-CoV-2 Omicron variant, which is known to accumulate a huge number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination. In this scenario, we evaluated the...

Descripción completa

Detalles Bibliográficos
Autores principales: Campos, Guilherme R. F., Almeida, Nathalie Bonatti Franco, Filgueiras, Priscilla Soares, Corsini, Camila Amormino, Gomes, Sarah Vieira Contin, de Miranda, Daniel Alvim Pena, de Assis, Jéssica Vieira, de Souza Silva, Thaís Bárbara, Alves, Pedro Augusto, da Rocha Fernandes, Gabriel, de Oliveira, Jaquelline Germano, Rahal, Paula, Queiroz, Rafaella Fortini Grenfelle, Nogueira, Maurício L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963699/
https://www.ncbi.nlm.nih.gov/pubmed/35350193
http://dx.doi.org/10.1101/2022.03.24.22272904
Descripción
Sumario:The emergence of the new SARS-CoV-2 Omicron variant, which is known to accumulate a huge number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination. In this scenario, we evaluated the impact on antibody neutralization induction, against Omicron variant, by a booster dose of BNT162b2 mRNA vaccine after the CoronaVac primary vaccination scheme. The percentage of seroconverted individuals 30 and 60 days after CoronaVac scheme was 17% and 10%, respectively. After booster dose administration, the seroconvertion rate increased to 76.6%. The neutralization mean titer against Omicron in the CoronaVac protocol decreased over time, but after the booster dose, the mean titer increased 43.1 times, indicating a positive impact of this vaccine combination in the serological immune response.

Ejemplares similares