Booster dose of BNT162b2 in a CoronaVac primary vaccination protocol improves neutralization of SARS-CoV-2 Omicron variant

The emergence of the new SARS-CoV-2 Omicron variant, which is known to accumulate a huge number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination. In this scenario, we evaluated the...

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Autores principales: Campos, Guilherme R. F., Almeida, Nathalie Bonatti Franco, Filgueiras, Priscilla Soares, Corsini, Camila Amormino, Gomes, Sarah Vieira Contin, de Miranda, Daniel Alvim Pena, de Assis, Jéssica Vieira, de Souza Silva, Thaís Bárbara, Alves, Pedro Augusto, da Rocha Fernandes, Gabriel, de Oliveira, Jaquelline Germano, Rahal, Paula, Queiroz, Rafaella Fortini Grenfelle, Nogueira, Maurício L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963699/
https://www.ncbi.nlm.nih.gov/pubmed/35350193
http://dx.doi.org/10.1101/2022.03.24.22272904
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author Campos, Guilherme R. F.
Almeida, Nathalie Bonatti Franco
Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Gomes, Sarah Vieira Contin
de Miranda, Daniel Alvim Pena
de Assis, Jéssica Vieira
de Souza Silva, Thaís Bárbara
Alves, Pedro Augusto
da Rocha Fernandes, Gabriel
de Oliveira, Jaquelline Germano
Rahal, Paula
Queiroz, Rafaella Fortini Grenfelle
Nogueira, Maurício L.
author_facet Campos, Guilherme R. F.
Almeida, Nathalie Bonatti Franco
Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Gomes, Sarah Vieira Contin
de Miranda, Daniel Alvim Pena
de Assis, Jéssica Vieira
de Souza Silva, Thaís Bárbara
Alves, Pedro Augusto
da Rocha Fernandes, Gabriel
de Oliveira, Jaquelline Germano
Rahal, Paula
Queiroz, Rafaella Fortini Grenfelle
Nogueira, Maurício L.
author_sort Campos, Guilherme R. F.
collection PubMed
description The emergence of the new SARS-CoV-2 Omicron variant, which is known to accumulate a huge number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination. In this scenario, we evaluated the impact on antibody neutralization induction, against Omicron variant, by a booster dose of BNT162b2 mRNA vaccine after the CoronaVac primary vaccination scheme. The percentage of seroconverted individuals 30 and 60 days after CoronaVac scheme was 17% and 10%, respectively. After booster dose administration, the seroconvertion rate increased to 76.6%. The neutralization mean titer against Omicron in the CoronaVac protocol decreased over time, but after the booster dose, the mean titer increased 43.1 times, indicating a positive impact of this vaccine combination in the serological immune response.
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spelling pubmed-89636992022-03-30 Booster dose of BNT162b2 in a CoronaVac primary vaccination protocol improves neutralization of SARS-CoV-2 Omicron variant Campos, Guilherme R. F. Almeida, Nathalie Bonatti Franco Filgueiras, Priscilla Soares Corsini, Camila Amormino Gomes, Sarah Vieira Contin de Miranda, Daniel Alvim Pena de Assis, Jéssica Vieira de Souza Silva, Thaís Bárbara Alves, Pedro Augusto da Rocha Fernandes, Gabriel de Oliveira, Jaquelline Germano Rahal, Paula Queiroz, Rafaella Fortini Grenfelle Nogueira, Maurício L. medRxiv Article The emergence of the new SARS-CoV-2 Omicron variant, which is known to accumulate a huge number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination. In this scenario, we evaluated the impact on antibody neutralization induction, against Omicron variant, by a booster dose of BNT162b2 mRNA vaccine after the CoronaVac primary vaccination scheme. The percentage of seroconverted individuals 30 and 60 days after CoronaVac scheme was 17% and 10%, respectively. After booster dose administration, the seroconvertion rate increased to 76.6%. The neutralization mean titer against Omicron in the CoronaVac protocol decreased over time, but after the booster dose, the mean titer increased 43.1 times, indicating a positive impact of this vaccine combination in the serological immune response. Cold Spring Harbor Laboratory 2022-03-25 /pmc/articles/PMC8963699/ /pubmed/35350193 http://dx.doi.org/10.1101/2022.03.24.22272904 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Campos, Guilherme R. F.
Almeida, Nathalie Bonatti Franco
Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Gomes, Sarah Vieira Contin
de Miranda, Daniel Alvim Pena
de Assis, Jéssica Vieira
de Souza Silva, Thaís Bárbara
Alves, Pedro Augusto
da Rocha Fernandes, Gabriel
de Oliveira, Jaquelline Germano
Rahal, Paula
Queiroz, Rafaella Fortini Grenfelle
Nogueira, Maurício L.
Booster dose of BNT162b2 in a CoronaVac primary vaccination protocol improves neutralization of SARS-CoV-2 Omicron variant
title Booster dose of BNT162b2 in a CoronaVac primary vaccination protocol improves neutralization of SARS-CoV-2 Omicron variant
title_full Booster dose of BNT162b2 in a CoronaVac primary vaccination protocol improves neutralization of SARS-CoV-2 Omicron variant
title_fullStr Booster dose of BNT162b2 in a CoronaVac primary vaccination protocol improves neutralization of SARS-CoV-2 Omicron variant
title_full_unstemmed Booster dose of BNT162b2 in a CoronaVac primary vaccination protocol improves neutralization of SARS-CoV-2 Omicron variant
title_short Booster dose of BNT162b2 in a CoronaVac primary vaccination protocol improves neutralization of SARS-CoV-2 Omicron variant
title_sort booster dose of bnt162b2 in a coronavac primary vaccination protocol improves neutralization of sars-cov-2 omicron variant
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963699/
https://www.ncbi.nlm.nih.gov/pubmed/35350193
http://dx.doi.org/10.1101/2022.03.24.22272904
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