Cargando…

Fenofibrate Increases the Population of Non-Classical Monocytes in Asymptomatic Chagas Disease Patients and Modulates Inflammatory Cytokines in PBMC

Chronic Chagas disease cardiomyopathy (CCC) is the most important clinical manifestation of infection with Trypanosma cruzi (T. cruzi) due to its frequency and effects on morbidity and mortality. Peripheral blood mononuclear cells (PBMC) infiltrate the tissue and differentiate into inflammatory macr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pieralisi, Azul V., Cevey, Ágata C., Penas, Federico N., Prado, Nilda, Mori, Ana, Gili, Mónica, Mirkin, Gerardo A., Gagliardi, Juan, Goren, Nora B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963737/ https://www.ncbi.nlm.nih.gov/pubmed/35360222 http://dx.doi.org/10.3389/fcimb.2021.785166

Ejemplares similares

IL-10-Dependent and -Independent Mechanisms Are Involved in the Cardiac Pathology Modulation Mediated by Fenofibrate in an Experimental Model of Chagas Heart Disease
por: Rada, Jimena, et al.
Publicado: (2020)

Treatment with Fenofibrate plus a low dose of Benznidazole attenuates cardiac dysfunction in experimental Chagas disease
por: Cevey, Ágata C., et al.
Publicado: (2017)

Benznidazole Anti-Inflammatory Effects in Murine Cardiomyocytes and Macrophages Are Mediated by Class I PI3Kδ
por: Cevey, Ágata C., et al.
Publicado: (2021)

Pyridinecarboxylic Acid Derivative Stimulates Pro-Angiogenic Mediators by PI3K/AKT/mTOR and Inhibits Reactive Nitrogen and Oxygen Species and NF-κB Activation Through a PPARγ-Dependent Pathway in T. cruzi-Infected Macrophages
por: Penas, Federico Nicolás, et al.
Publicado: (2020)

Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain
por: Cevey, Ágata Carolina, et al.
Publicado: (2015)

Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy
por: Hovsepian, Eugenia, et al.
Publicado: (2012)

IL-10/STAT3/SOCS3 Axis Is Involved in the Anti-inflammatory Effect of Benznidazole
por: Cevey, Ágata C., et al.
Publicado: (2019)

Studies on the contribution of PPAR Gamma to tuberculosis physiopathology
por: Díaz, Ariana, et al.
Publicado: (2023)

Differential Expression of Immune Response Genes in Asymptomatic Chronic Chagas Disease Patients Versus Healthy Subjects
por: Gómez, Inmaculada, et al.
Publicado: (2021)

Treatment with a New Peroxisome Proliferator-Activated Receptor Gamma Agonist, Pyridinecarboxylic Acid Derivative, Increases Angiogenesis and Reduces Inflammatory Mediators in the Heart of Trypanosoma cruzi-Infected Mice
por: Penas, Federico Nicolás, et al.
Publicado: (2017)

Single-cell sequencing of PBMC characterizes the altered transcriptomic landscape of classical monocytes in BNT162b2-induced myocarditis
por: Hwang, Nahee, et al.
Publicado: (2022)

Gut Dysbiosis in Chagas Disease. A Possible Link to the Pathogenesis
por: de Souza-Basqueira, Marcela, et al.
Publicado: (2020)

IL-10 Inhibits the NF-κB and ERK/MAPK-Mediated Production of Pro-Inflammatory Mediators by Up-Regulation of SOCS-3 in Trypanosoma cruzi-Infected Cardiomyocytes
por: Hovsepian, Eugenia, et al.
Publicado: (2013)

CD86 Expression by Monocytes Influences an Immunomodulatory Profile in Asymptomatic Patients with Chronic Chagas Disease
por: Pinto, Bruna F., et al.
Publicado: (2018)

Fenofibrate Ameliorated Systemic and Retinal Inflammation and Modulated Gut Microbiota in High-Fat Diet-Induced Mice
por: Wang, Xue, et al.
Publicado: (2022)

Editorial: World Chagas disease day 2022
por: Palmisano, Giuseppe, et al.
Publicado: (2023)

Early Detection of Chronic Asymptomatic Chagas Infection
por: de la Rosa, Ezequiel, et al.
Publicado: (2018)

Discovery and Genetic Validation of Chemotherapeutic Targets for Chagas' Disease
por: Osorio-Méndez, Juan Felipe, et al.
Publicado: (2019)

Editorial: Chagas disease novel drug targets and treatments
por: Duschak, Vilma G., et al.
Publicado: (2023)

A Review of Currently Available Fenofibrate and Fenofibric Acid Formulations
por: Ling, Hua, et al.
Publicado: (2013)

Activation of Interleukin-1β Release by the Classical Swine Fever Virus Is Dependent on the NLRP3 Inflammasome, Which Affects Virus Growth in Monocytes
por: Fan, Shuangqi, et al.
Publicado: (2018)

Heart Rate Recovery in Asymptomatic Patients with Chagas Disease
por: de Alencar, Maria Clara Noman, et al.
Publicado: (2014)

Use of tissue doppler imaging for the early detection of myocardial dysfunction in patients with the indeterminate form of Chagas disease
por: Cianciulli, Tomás Francisco, et al.
Publicado: (2020)

Air Pollution’s Impact on Cardiac Remodeling in an Experimental Model of Chagas Cardiomyopathy
por: Fonseca, Keila Cardoso Barbosa, et al.
Publicado: (2022)

Circulating MicroRNAs and myocardial involvement severity in chronic Chagas cardiomyopathy
por: Gómez-Ochoa, Sergio Alejandro, et al.
Publicado: (2022)

Role of the Complement System in the Modulation of T-Cell Responses in Chronic Chagas Disease
por: Caputo, María Belén, et al.
Publicado: (2022)

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?
por: Scariot, Debora B., et al.
Publicado: (2022)

A rare case of asymptomatic emphysematous pyelonephritis
por: Yeung, AMH, et al.
Publicado: (2019)

Extracellular vesicles from serum samples of mycobacteria patients induced cell death of THP-1 monocyte and PBMC
por: Javadi, Alireza, et al.
Publicado: (2022)

Early detection of left ventricular diastolic dysfunction in Chagas' disease
por: Cianciulli, Tomás F, et al.
Publicado: (2006)

Archaea Symbiont of T. cruzi Infection May Explain Heart Failure in Chagas Disease
por: Higuchi, Maria de Lourdes, et al.
Publicado: (2018)

Sirtuin Control of Mitochondrial Dysfunction, Oxidative Stress, and Inflammation in Chagas Disease Models
por: Wan, Xianxiu, et al.
Publicado: (2021)

Aging of classical monocyte subsets
por: Goodridge, Helen S.
Publicado: (2023)

Trypanosoma cruzi trans-Sialidase as a Potential Vaccine Target Against Chagas Disease
por: da Costa, Kelli Monteiro, et al.
Publicado: (2021)

Trypanosoma cruzi Induces Regulatory B Cell Alterations in Patients With Chronic Chagas Disease
por: Girard, Magalí C., et al.
Publicado: (2021)

The Search for Biomarkers and Treatments in Chagas Disease: Insights From TGF-Beta Studies and Immunogenetics
por: Ferreira, Roberto Rodrigues, et al.
Publicado: (2022)

Does Autoimmunity Play a Role in the Immunopathogenesis of Vasculitis Associated With Chronic Chagas Disease?
por: Garcia-Bustos, Victor, et al.
Publicado: (2021)

Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy
por: Santos, Emanuelle de Souza, et al.
Publicado: (2021)

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
por: Jain, Surendra K., et al.
Publicado: (2012)

A review on the rationale and clinical use of concomitant rosuvastatin and fenofibrate/fenofibric acid therapy
por: Strain, Joe D, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_6cfc5g9u0mgp63oub80sl2d15s