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Severe Cholestatic Hepatitis Secondary to SARS-CoV-2
Liver injury is a common manifestation of coronavirus disease 2019 (COVID-19), with most injuries manifesting as transient mild hepatocellular injury. Cholestatic injury occurs less commonly and is typically mild. Severe cholestatic injury is rare, with only 4 cases reported in the literature. We pr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963841/ https://www.ncbi.nlm.nih.gov/pubmed/35359752 http://dx.doi.org/10.14309/crj.0000000000000753 |
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author | Lindholm, Christopher R. Zhang, Xiaofei Spengler, Erin K. Daniel, Kimberly E. |
author_facet | Lindholm, Christopher R. Zhang, Xiaofei Spengler, Erin K. Daniel, Kimberly E. |
author_sort | Lindholm, Christopher R. |
collection | PubMed |
description | Liver injury is a common manifestation of coronavirus disease 2019 (COVID-19), with most injuries manifesting as transient mild hepatocellular injury. Cholestatic injury occurs less commonly and is typically mild. Severe cholestatic injury is rare, with only 4 cases reported in the literature. We present a 70-year-old woman with no known liver disease who presented with severe COVID-19 and developed severe cholestatic hepatitis. A liver biopsy was performed demonstrating bile duct injury, uncommonly reported in patients with COVID-19. This complication needs greater awareness because it has been known to cause progressive liver disease requiring transplantation. |
format | Online Article Text |
id | pubmed-8963841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-89638412022-03-30 Severe Cholestatic Hepatitis Secondary to SARS-CoV-2 Lindholm, Christopher R. Zhang, Xiaofei Spengler, Erin K. Daniel, Kimberly E. ACG Case Rep J Case Report Liver injury is a common manifestation of coronavirus disease 2019 (COVID-19), with most injuries manifesting as transient mild hepatocellular injury. Cholestatic injury occurs less commonly and is typically mild. Severe cholestatic injury is rare, with only 4 cases reported in the literature. We present a 70-year-old woman with no known liver disease who presented with severe COVID-19 and developed severe cholestatic hepatitis. A liver biopsy was performed demonstrating bile duct injury, uncommonly reported in patients with COVID-19. This complication needs greater awareness because it has been known to cause progressive liver disease requiring transplantation. Wolters Kluwer 2022-03-28 /pmc/articles/PMC8963841/ /pubmed/35359752 http://dx.doi.org/10.14309/crj.0000000000000753 Text en © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Case Report Lindholm, Christopher R. Zhang, Xiaofei Spengler, Erin K. Daniel, Kimberly E. Severe Cholestatic Hepatitis Secondary to SARS-CoV-2 |
title | Severe Cholestatic Hepatitis Secondary to SARS-CoV-2 |
title_full | Severe Cholestatic Hepatitis Secondary to SARS-CoV-2 |
title_fullStr | Severe Cholestatic Hepatitis Secondary to SARS-CoV-2 |
title_full_unstemmed | Severe Cholestatic Hepatitis Secondary to SARS-CoV-2 |
title_short | Severe Cholestatic Hepatitis Secondary to SARS-CoV-2 |
title_sort | severe cholestatic hepatitis secondary to sars-cov-2 |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963841/ https://www.ncbi.nlm.nih.gov/pubmed/35359752 http://dx.doi.org/10.14309/crj.0000000000000753 |
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