Azepine-Indole Alkaloids From Psychotria nemorosa Modulate 5-HT(2A) Receptors and Prevent in vivo Protein Toxicity in Transgenic Caenorhabditis elegans

Nemorosine A (1) and fargesine (2), the main azepine-indole alkaloids of Psychotria nemorosa, were explored for their pharmacological profile on neurodegenerative disorders (NDs) applying a combined in silico–in vitro–in vivo approach. By using 1 and 2 as queries for similarity-based searches of the...

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Detalles Bibliográficos
Autores principales: Kirchweger, Benjamin, Klein-Junior, Luiz C., Pretsch, Dagmar, Chen, Ya, Cretton, Sylvian, Gasper, André L., Heyden, Yvan Vander, Christen, Philippe, Kirchmair, Johannes, Henriques, Amélia T., Rollinger, Judith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963987/
https://www.ncbi.nlm.nih.gov/pubmed/35360162
http://dx.doi.org/10.3389/fnins.2022.826289

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