Streamlining the Characterization of Disulfide Bond Shuffling and Protein Degradation in IgG1 Biopharmaceuticals Under Native and Stressed Conditions

Post translational modifications (PTMs) have been shown to negatively impact protein efficacy and safety by altering its native conformation, stability, target binding and/or pharmacokinetics. One PTM in particular, shuffled disulfide bonds, has been linked to decreased potency and increased immunog...

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Detalles Bibliográficos
Autores principales: Coghlan, Jill, Benet, Alexander, Kumaran, Preethi, Ford, Michael, Veale, Lawrie, Skilton, St. John, Saveliev, Sergei, Schwendeman, Anna A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963993/
https://www.ncbi.nlm.nih.gov/pubmed/35360407
http://dx.doi.org/10.3389/fbioe.2022.862456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963993/
https://www.ncbi.nlm.nih.gov/pubmed/35360407
http://dx.doi.org/10.3389/fbioe.2022.862456

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