Ritonavir-Boosted Exposure of Kinase Inhibitors: an Open Label, Cross-over Pharmacokinetic Proof-of-Concept Trial with Erlotinib

BACKGROUND: Although kinase inhibitors (KIs) are generally effective, their use has a large impact on the current health care budget. Dosing strategies to reduce treatment costs are warranted. Boosting pharmacokinetic exposure of KIs metabolized by cytochrome P450 (CYP)3A4 with ritonavir might resul...

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Detalles Bibliográficos
Autores principales: Boosman, René J., de Gooijer, Cornedine J., Groenland, Stefanie L., Burgers, Jacobus A., Baas, Paul, van der Noort, Vincent, Beijnen, Jos H., Huitema, Alwin D.R., Steeghs, Neeltje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964029/
https://www.ncbi.nlm.nih.gov/pubmed/35352280
http://dx.doi.org/10.1007/s11095-022-03244-8

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