Case Report: Anti-NF186+ CIDP After Receiving the Inactivated Vaccine for Coronavirus Disease (COVID-19)

Corona Virus Disease 2019 (COVID-19), the novel coronavirus disease, is now a global pandemic. Vaccination can significantly reduce the mortality rate caused by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2). There are currently several effective vaccines that have been introduc...

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Autores principales: Wen, Shirui, Huang, Kailing, Zhu, Haoyue, Li, Peihong, Zhou, Luo, Feng, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964034/
https://www.ncbi.nlm.nih.gov/pubmed/35359644
http://dx.doi.org/10.3389/fneur.2022.838222
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author Wen, Shirui
Huang, Kailing
Zhu, Haoyue
Li, Peihong
Zhou, Luo
Feng, Li
author_facet Wen, Shirui
Huang, Kailing
Zhu, Haoyue
Li, Peihong
Zhou, Luo
Feng, Li
author_sort Wen, Shirui
collection PubMed
description Corona Virus Disease 2019 (COVID-19), the novel coronavirus disease, is now a global pandemic. Vaccination can significantly reduce the mortality rate caused by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2). There are currently several effective vaccines that have been introduced. Inactivated COVID-19 vaccine is one of these options and is generally considered safe. Neurofascin (NF) plays an important role in keeping the functionality of the node of Ranvier. We report here a rare case of anti-NF186+ chronic inflammatory demyelinating polyneuropathy (CIDP) in a 23-year-old male patient who was vaccinated with inactivated COVID-19 vaccine prior to the onset. This report adds a new possible rare side effect of a COVID-19 vaccine and provides a case for the clinical effectiveness of rituximab (RTX) in patients with anti-NF186+ CIDP.
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spelling pubmed-89640342022-03-30 Case Report: Anti-NF186+ CIDP After Receiving the Inactivated Vaccine for Coronavirus Disease (COVID-19) Wen, Shirui Huang, Kailing Zhu, Haoyue Li, Peihong Zhou, Luo Feng, Li Front Neurol Neurology Corona Virus Disease 2019 (COVID-19), the novel coronavirus disease, is now a global pandemic. Vaccination can significantly reduce the mortality rate caused by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2). There are currently several effective vaccines that have been introduced. Inactivated COVID-19 vaccine is one of these options and is generally considered safe. Neurofascin (NF) plays an important role in keeping the functionality of the node of Ranvier. We report here a rare case of anti-NF186+ chronic inflammatory demyelinating polyneuropathy (CIDP) in a 23-year-old male patient who was vaccinated with inactivated COVID-19 vaccine prior to the onset. This report adds a new possible rare side effect of a COVID-19 vaccine and provides a case for the clinical effectiveness of rituximab (RTX) in patients with anti-NF186+ CIDP. Frontiers Media S.A. 2022-03-14 /pmc/articles/PMC8964034/ /pubmed/35359644 http://dx.doi.org/10.3389/fneur.2022.838222 Text en Copyright © 2022 Wen, Huang, Zhu, Li, Zhou and Feng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Wen, Shirui
Huang, Kailing
Zhu, Haoyue
Li, Peihong
Zhou, Luo
Feng, Li
Case Report: Anti-NF186+ CIDP After Receiving the Inactivated Vaccine for Coronavirus Disease (COVID-19)
title Case Report: Anti-NF186+ CIDP After Receiving the Inactivated Vaccine for Coronavirus Disease (COVID-19)
title_full Case Report: Anti-NF186+ CIDP After Receiving the Inactivated Vaccine for Coronavirus Disease (COVID-19)
title_fullStr Case Report: Anti-NF186+ CIDP After Receiving the Inactivated Vaccine for Coronavirus Disease (COVID-19)
title_full_unstemmed Case Report: Anti-NF186+ CIDP After Receiving the Inactivated Vaccine for Coronavirus Disease (COVID-19)
title_short Case Report: Anti-NF186+ CIDP After Receiving the Inactivated Vaccine for Coronavirus Disease (COVID-19)
title_sort case report: anti-nf186+ cidp after receiving the inactivated vaccine for coronavirus disease (covid-19)
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964034/
https://www.ncbi.nlm.nih.gov/pubmed/35359644
http://dx.doi.org/10.3389/fneur.2022.838222
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