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Knockdown of Amyloid Precursor Protein: Biological Consequences and Clinical Opportunities

Amyloid precursor protein (APP) and its cleavage fragment Amyloid-β (Aβ) have fundamental roles in Alzheimer’s disease (AD). Genetic alterations that either increase the overall dosage of APP or alter its processing to favour the generation of longer, more aggregation prone Aβ species, are directly...

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Detalles Bibliográficos
Autores principales:	Gabriele, Rebecca M. C., Abel, Emily, Fox, Nick C., Wray, Selina, Arber, Charles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964081/ https://www.ncbi.nlm.nih.gov/pubmed/35360155 http://dx.doi.org/10.3389/fnins.2022.835645

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