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Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development
Emerging evidence shows that m(6)A is the most abundant modification in eukaryotic RNA molecules. It has only recently been found that this epigenetic modification plays an important role in many physiological and pathological processes, such as cell fate commitment, immune response, obesity, tumori...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964082/ https://www.ncbi.nlm.nih.gov/pubmed/35359444 http://dx.doi.org/10.3389/fcell.2022.819044 |
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author | Chang, Yuguang Yi, Mingliang Wang, Jing Cao, Zhikun Zhou, Tingting Ge, Wei Muhammad, Zafir Zhang, Zijun Feng, Yanqin Yan, Zihui Felici, Massimo De Shen, Wei Cao, Hongguo |
author_facet | Chang, Yuguang Yi, Mingliang Wang, Jing Cao, Zhikun Zhou, Tingting Ge, Wei Muhammad, Zafir Zhang, Zijun Feng, Yanqin Yan, Zihui Felici, Massimo De Shen, Wei Cao, Hongguo |
author_sort | Chang, Yuguang |
collection | PubMed |
description | Emerging evidence shows that m(6)A is the most abundant modification in eukaryotic RNA molecules. It has only recently been found that this epigenetic modification plays an important role in many physiological and pathological processes, such as cell fate commitment, immune response, obesity, tumorigenesis, and relevant for the present review, gametogenesis. Notably the RNA metabolism process mediated by m(6)A is controlled and regulated by a series of proteins termed writers, readers and erasers that are highly expressed in germ cells and somatic cells of gonads. Here, we review and discuss the expression and the functional emerging roles of m(6)A in gametogenesis and early embryogenesis of mammals. Besides updated references about such new topics, readers might find in the present work inspiration and clues to elucidate epigenetic molecular mechanisms of reproductive dysfunction and perspectives for future research. |
format | Online Article Text |
id | pubmed-8964082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89640822022-03-30 Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development Chang, Yuguang Yi, Mingliang Wang, Jing Cao, Zhikun Zhou, Tingting Ge, Wei Muhammad, Zafir Zhang, Zijun Feng, Yanqin Yan, Zihui Felici, Massimo De Shen, Wei Cao, Hongguo Front Cell Dev Biol Cell and Developmental Biology Emerging evidence shows that m(6)A is the most abundant modification in eukaryotic RNA molecules. It has only recently been found that this epigenetic modification plays an important role in many physiological and pathological processes, such as cell fate commitment, immune response, obesity, tumorigenesis, and relevant for the present review, gametogenesis. Notably the RNA metabolism process mediated by m(6)A is controlled and regulated by a series of proteins termed writers, readers and erasers that are highly expressed in germ cells and somatic cells of gonads. Here, we review and discuss the expression and the functional emerging roles of m(6)A in gametogenesis and early embryogenesis of mammals. Besides updated references about such new topics, readers might find in the present work inspiration and clues to elucidate epigenetic molecular mechanisms of reproductive dysfunction and perspectives for future research. Frontiers Media S.A. 2022-03-14 /pmc/articles/PMC8964082/ /pubmed/35359444 http://dx.doi.org/10.3389/fcell.2022.819044 Text en Copyright © 2022 Chang, Yi, Wang, Cao, Zhou, Ge, Muhammad, Zhang, Feng, Yan, Felici, Shen and Cao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Chang, Yuguang Yi, Mingliang Wang, Jing Cao, Zhikun Zhou, Tingting Ge, Wei Muhammad, Zafir Zhang, Zijun Feng, Yanqin Yan, Zihui Felici, Massimo De Shen, Wei Cao, Hongguo Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development |
title | Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development |
title_full | Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development |
title_fullStr | Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development |
title_full_unstemmed | Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development |
title_short | Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development |
title_sort | genetic regulation of n6-methyladenosine-rna in mammalian gametogenesis and embryonic development |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964082/ https://www.ncbi.nlm.nih.gov/pubmed/35359444 http://dx.doi.org/10.3389/fcell.2022.819044 |
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