Five Hours Total Sleep Deprivation Does Not Affect CA1 Dendritic Length or Spine Density

Sleep is essential for long term memory function. However, the neuroanatomical consequences of sleep loss are disputed. Sleep deprivation has been reported to cause both decreases and increases of dendritic spine density. Here we use Thy1-GFP expressing transgenic mice to investigate the effects of...

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Autores principales: Brodin, Alvin T. S., Gabulya, Sarolta, Wellfelt, Katrin, Karlsson, Tobias E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964138/
https://www.ncbi.nlm.nih.gov/pubmed/35359703
http://dx.doi.org/10.3389/fnsyn.2022.854160
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author Brodin, Alvin T. S.
Gabulya, Sarolta
Wellfelt, Katrin
Karlsson, Tobias E.
author_facet Brodin, Alvin T. S.
Gabulya, Sarolta
Wellfelt, Katrin
Karlsson, Tobias E.
author_sort Brodin, Alvin T. S.
collection PubMed
description Sleep is essential for long term memory function. However, the neuroanatomical consequences of sleep loss are disputed. Sleep deprivation has been reported to cause both decreases and increases of dendritic spine density. Here we use Thy1-GFP expressing transgenic mice to investigate the effects of acute sleep deprivation on the dendritic architecture of hippocampal CA1 pyramidal neurons. We found that 5 h of sleep deprivation had no effect on either dendritic length or dendritic spine density. Our work suggests that no major neuroanatomical changes result from a single episode of sleep deprivation.
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spelling pubmed-89641382022-03-30 Five Hours Total Sleep Deprivation Does Not Affect CA1 Dendritic Length or Spine Density Brodin, Alvin T. S. Gabulya, Sarolta Wellfelt, Katrin Karlsson, Tobias E. Front Synaptic Neurosci Neuroscience Sleep is essential for long term memory function. However, the neuroanatomical consequences of sleep loss are disputed. Sleep deprivation has been reported to cause both decreases and increases of dendritic spine density. Here we use Thy1-GFP expressing transgenic mice to investigate the effects of acute sleep deprivation on the dendritic architecture of hippocampal CA1 pyramidal neurons. We found that 5 h of sleep deprivation had no effect on either dendritic length or dendritic spine density. Our work suggests that no major neuroanatomical changes result from a single episode of sleep deprivation. Frontiers Media S.A. 2022-03-14 /pmc/articles/PMC8964138/ /pubmed/35359703 http://dx.doi.org/10.3389/fnsyn.2022.854160 Text en Copyright © 2022 Brodin, Gabulya, Wellfelt and Karlsson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Brodin, Alvin T. S.
Gabulya, Sarolta
Wellfelt, Katrin
Karlsson, Tobias E.
Five Hours Total Sleep Deprivation Does Not Affect CA1 Dendritic Length or Spine Density
title Five Hours Total Sleep Deprivation Does Not Affect CA1 Dendritic Length or Spine Density
title_full Five Hours Total Sleep Deprivation Does Not Affect CA1 Dendritic Length or Spine Density
title_fullStr Five Hours Total Sleep Deprivation Does Not Affect CA1 Dendritic Length or Spine Density
title_full_unstemmed Five Hours Total Sleep Deprivation Does Not Affect CA1 Dendritic Length or Spine Density
title_short Five Hours Total Sleep Deprivation Does Not Affect CA1 Dendritic Length or Spine Density
title_sort five hours total sleep deprivation does not affect ca1 dendritic length or spine density
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964138/
https://www.ncbi.nlm.nih.gov/pubmed/35359703
http://dx.doi.org/10.3389/fnsyn.2022.854160
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