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The Dual Role of USP11 in Cancer

Ubiquitination is one of the most crucial ways of protein degradation and plays an indispensable role in various living activities of cells. The deubiquitinating enzyme (DUB) is the main practitioner of the reversal of ubiquitination. Up till the present moment, nearly 100 DUBs from six families hav...

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Detalles Bibliográficos
Autores principales: Guo, Tuanjie, Tang, Heting, Yuan, Zhihao, Zhang, Encheng, Wang, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964208/
https://www.ncbi.nlm.nih.gov/pubmed/35359344
http://dx.doi.org/10.1155/2022/9963905
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author Guo, Tuanjie
Tang, Heting
Yuan, Zhihao
Zhang, Encheng
Wang, Xiang
author_facet Guo, Tuanjie
Tang, Heting
Yuan, Zhihao
Zhang, Encheng
Wang, Xiang
author_sort Guo, Tuanjie
collection PubMed
description Ubiquitination is one of the most crucial ways of protein degradation and plays an indispensable role in various living activities of cells. The deubiquitinating enzyme (DUB) is the main practitioner of the reversal of ubiquitination. Up till the present moment, nearly 100 DUBs from six families have been confirmed. USP11 is a member of the largest subfamily of cysteine protease DUBs, involving in the regulation of cell cycle, DNA repair, regulating signaling pathways, tumor development, and other important biological behaviors. This review briefly describes the structure and function of USP11 and comprehensively describes its dual role in tumorigenesis and development, as well as its targeted therapy.
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spelling pubmed-89642082022-03-30 The Dual Role of USP11 in Cancer Guo, Tuanjie Tang, Heting Yuan, Zhihao Zhang, Encheng Wang, Xiang J Oncol Review Article Ubiquitination is one of the most crucial ways of protein degradation and plays an indispensable role in various living activities of cells. The deubiquitinating enzyme (DUB) is the main practitioner of the reversal of ubiquitination. Up till the present moment, nearly 100 DUBs from six families have been confirmed. USP11 is a member of the largest subfamily of cysteine protease DUBs, involving in the regulation of cell cycle, DNA repair, regulating signaling pathways, tumor development, and other important biological behaviors. This review briefly describes the structure and function of USP11 and comprehensively describes its dual role in tumorigenesis and development, as well as its targeted therapy. Hindawi 2022-03-22 /pmc/articles/PMC8964208/ /pubmed/35359344 http://dx.doi.org/10.1155/2022/9963905 Text en Copyright © 2022 Tuanjie Guo et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Guo, Tuanjie
Tang, Heting
Yuan, Zhihao
Zhang, Encheng
Wang, Xiang
The Dual Role of USP11 in Cancer
title The Dual Role of USP11 in Cancer
title_full The Dual Role of USP11 in Cancer
title_fullStr The Dual Role of USP11 in Cancer
title_full_unstemmed The Dual Role of USP11 in Cancer
title_short The Dual Role of USP11 in Cancer
title_sort dual role of usp11 in cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964208/
https://www.ncbi.nlm.nih.gov/pubmed/35359344
http://dx.doi.org/10.1155/2022/9963905
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