Cargando…
The Dual Role of USP11 in Cancer
Ubiquitination is one of the most crucial ways of protein degradation and plays an indispensable role in various living activities of cells. The deubiquitinating enzyme (DUB) is the main practitioner of the reversal of ubiquitination. Up till the present moment, nearly 100 DUBs from six families hav...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964208/ https://www.ncbi.nlm.nih.gov/pubmed/35359344 http://dx.doi.org/10.1155/2022/9963905 |
_version_ | 1784678161540186112 |
---|---|
author | Guo, Tuanjie Tang, Heting Yuan, Zhihao Zhang, Encheng Wang, Xiang |
author_facet | Guo, Tuanjie Tang, Heting Yuan, Zhihao Zhang, Encheng Wang, Xiang |
author_sort | Guo, Tuanjie |
collection | PubMed |
description | Ubiquitination is one of the most crucial ways of protein degradation and plays an indispensable role in various living activities of cells. The deubiquitinating enzyme (DUB) is the main practitioner of the reversal of ubiquitination. Up till the present moment, nearly 100 DUBs from six families have been confirmed. USP11 is a member of the largest subfamily of cysteine protease DUBs, involving in the regulation of cell cycle, DNA repair, regulating signaling pathways, tumor development, and other important biological behaviors. This review briefly describes the structure and function of USP11 and comprehensively describes its dual role in tumorigenesis and development, as well as its targeted therapy. |
format | Online Article Text |
id | pubmed-8964208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-89642082022-03-30 The Dual Role of USP11 in Cancer Guo, Tuanjie Tang, Heting Yuan, Zhihao Zhang, Encheng Wang, Xiang J Oncol Review Article Ubiquitination is one of the most crucial ways of protein degradation and plays an indispensable role in various living activities of cells. The deubiquitinating enzyme (DUB) is the main practitioner of the reversal of ubiquitination. Up till the present moment, nearly 100 DUBs from six families have been confirmed. USP11 is a member of the largest subfamily of cysteine protease DUBs, involving in the regulation of cell cycle, DNA repair, regulating signaling pathways, tumor development, and other important biological behaviors. This review briefly describes the structure and function of USP11 and comprehensively describes its dual role in tumorigenesis and development, as well as its targeted therapy. Hindawi 2022-03-22 /pmc/articles/PMC8964208/ /pubmed/35359344 http://dx.doi.org/10.1155/2022/9963905 Text en Copyright © 2022 Tuanjie Guo et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Guo, Tuanjie Tang, Heting Yuan, Zhihao Zhang, Encheng Wang, Xiang The Dual Role of USP11 in Cancer |
title | The Dual Role of USP11 in Cancer |
title_full | The Dual Role of USP11 in Cancer |
title_fullStr | The Dual Role of USP11 in Cancer |
title_full_unstemmed | The Dual Role of USP11 in Cancer |
title_short | The Dual Role of USP11 in Cancer |
title_sort | dual role of usp11 in cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964208/ https://www.ncbi.nlm.nih.gov/pubmed/35359344 http://dx.doi.org/10.1155/2022/9963905 |
work_keys_str_mv | AT guotuanjie thedualroleofusp11incancer AT tangheting thedualroleofusp11incancer AT yuanzhihao thedualroleofusp11incancer AT zhangencheng thedualroleofusp11incancer AT wangxiang thedualroleofusp11incancer AT guotuanjie dualroleofusp11incancer AT tangheting dualroleofusp11incancer AT yuanzhihao dualroleofusp11incancer AT zhangencheng dualroleofusp11incancer AT wangxiang dualroleofusp11incancer |