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The 14-3-3 Protein Family and Schizophrenia

Schizophrenia is a debilitating mental disorder that affects approximately 1% of the world population, yet the disorder is not very well understood. The genetics of schizophrenia is very heterogenous, making it hard to pinpoint specific alterations that may cause the disorder. However, there is grow...

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Autores principales: Navarrete, Meaghan, Zhou, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964262/
https://www.ncbi.nlm.nih.gov/pubmed/35359567
http://dx.doi.org/10.3389/fnmol.2022.857495
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author Navarrete, Meaghan
Zhou, Yi
author_facet Navarrete, Meaghan
Zhou, Yi
author_sort Navarrete, Meaghan
collection PubMed
description Schizophrenia is a debilitating mental disorder that affects approximately 1% of the world population, yet the disorder is not very well understood. The genetics of schizophrenia is very heterogenous, making it hard to pinpoint specific alterations that may cause the disorder. However, there is growing evidence from human studies suggesting a link between alterations in the 14-3-3 family and schizophrenia. The 14-3-3 proteins are abundantly expressed in the brain and are involved in many important cellular processes. Knockout of 14-3-3 proteins in mice has been shown to cause molecular, structural, and behavioral alterations associated with schizophrenia. Thus, 14-3-3 animal models allow for further exploration of the relationship between 14-3-3 and schizophrenia as well as the study of schizophrenia pathology. This review considers evidence from both human and animal model studies that implicate the 14-3-3 family in schizophrenia. In addition, possible mechanisms by which alterations in 14-3-3 proteins may contribute to schizophrenia-like phenotypes such as dopaminergic, glutamatergic, and cytoskeletal dysregulations are discussed.
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spelling pubmed-89642622022-03-30 The 14-3-3 Protein Family and Schizophrenia Navarrete, Meaghan Zhou, Yi Front Mol Neurosci Neuroscience Schizophrenia is a debilitating mental disorder that affects approximately 1% of the world population, yet the disorder is not very well understood. The genetics of schizophrenia is very heterogenous, making it hard to pinpoint specific alterations that may cause the disorder. However, there is growing evidence from human studies suggesting a link between alterations in the 14-3-3 family and schizophrenia. The 14-3-3 proteins are abundantly expressed in the brain and are involved in many important cellular processes. Knockout of 14-3-3 proteins in mice has been shown to cause molecular, structural, and behavioral alterations associated with schizophrenia. Thus, 14-3-3 animal models allow for further exploration of the relationship between 14-3-3 and schizophrenia as well as the study of schizophrenia pathology. This review considers evidence from both human and animal model studies that implicate the 14-3-3 family in schizophrenia. In addition, possible mechanisms by which alterations in 14-3-3 proteins may contribute to schizophrenia-like phenotypes such as dopaminergic, glutamatergic, and cytoskeletal dysregulations are discussed. Frontiers Media S.A. 2022-03-14 /pmc/articles/PMC8964262/ /pubmed/35359567 http://dx.doi.org/10.3389/fnmol.2022.857495 Text en Copyright © 2022 Navarrete and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Navarrete, Meaghan
Zhou, Yi
The 14-3-3 Protein Family and Schizophrenia
title The 14-3-3 Protein Family and Schizophrenia
title_full The 14-3-3 Protein Family and Schizophrenia
title_fullStr The 14-3-3 Protein Family and Schizophrenia
title_full_unstemmed The 14-3-3 Protein Family and Schizophrenia
title_short The 14-3-3 Protein Family and Schizophrenia
title_sort 14-3-3 protein family and schizophrenia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964262/
https://www.ncbi.nlm.nih.gov/pubmed/35359567
http://dx.doi.org/10.3389/fnmol.2022.857495
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