Structure of UBE2K–Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension

Ubiquitin (Ub) chain types govern distinct biological processes. K48-linked polyUb chains target substrates for proteasomal degradation, but the mechanism of Ub chain synthesis remains elusive due to the transient nature of Ub handover. Here, we present the structure of a chemically trapped complex...

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Detalles Bibliográficos
Autores principales: Nakasone, Mark A., Majorek, Karolina A., Gabrielsen, Mads, Sibbet, Gary J., Smith, Brian O., Huang, Danny T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964413/
https://www.ncbi.nlm.nih.gov/pubmed/35027744
http://dx.doi.org/10.1038/s41589-021-00952-x

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