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Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks
Membrane proteins are an essential part of the body’s ability to maintain normal life activities. Further research into membrane proteins, which are present in all aspects of life science research, will help to advance the development of cells and drugs. The current methods for predicting proteins a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964460/ https://www.ncbi.nlm.nih.gov/pubmed/35371189 http://dx.doi.org/10.3389/fgene.2021.834488 |
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author | Lu, Weizhong Shen, Jiawei Zhang, Yu Wu, Hongjie Qian, Yuqing Chen, Xiaoyi Fu, Qiming |
author_facet | Lu, Weizhong Shen, Jiawei Zhang, Yu Wu, Hongjie Qian, Yuqing Chen, Xiaoyi Fu, Qiming |
author_sort | Lu, Weizhong |
collection | PubMed |
description | Membrane proteins are an essential part of the body’s ability to maintain normal life activities. Further research into membrane proteins, which are present in all aspects of life science research, will help to advance the development of cells and drugs. The current methods for predicting proteins are usually based on machine learning, but further improvements in prediction effectiveness and accuracy are needed. In this paper, we propose a dynamic deep network architecture based on lifelong learning in order to use computers to classify membrane proteins more effectively. The model extends the application area of lifelong learning and provides new ideas for multiple classification problems in bioinformatics. To demonstrate the performance of our model, we conducted experiments on top of two datasets and compared them with other classification methods. The results show that our model achieves high accuracy (95.3 and 93.5%) on benchmark datasets and is more effective compared to other methods. |
format | Online Article Text |
id | pubmed-8964460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89644602022-03-31 Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks Lu, Weizhong Shen, Jiawei Zhang, Yu Wu, Hongjie Qian, Yuqing Chen, Xiaoyi Fu, Qiming Front Genet Genetics Membrane proteins are an essential part of the body’s ability to maintain normal life activities. Further research into membrane proteins, which are present in all aspects of life science research, will help to advance the development of cells and drugs. The current methods for predicting proteins are usually based on machine learning, but further improvements in prediction effectiveness and accuracy are needed. In this paper, we propose a dynamic deep network architecture based on lifelong learning in order to use computers to classify membrane proteins more effectively. The model extends the application area of lifelong learning and provides new ideas for multiple classification problems in bioinformatics. To demonstrate the performance of our model, we conducted experiments on top of two datasets and compared them with other classification methods. The results show that our model achieves high accuracy (95.3 and 93.5%) on benchmark datasets and is more effective compared to other methods. Frontiers Media S.A. 2022-03-14 /pmc/articles/PMC8964460/ /pubmed/35371189 http://dx.doi.org/10.3389/fgene.2021.834488 Text en Copyright © 2022 Lu, Shen, Zhang, Wu, Qian, Chen and Fu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Lu, Weizhong Shen, Jiawei Zhang, Yu Wu, Hongjie Qian, Yuqing Chen, Xiaoyi Fu, Qiming Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks |
title | Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks |
title_full | Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks |
title_fullStr | Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks |
title_full_unstemmed | Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks |
title_short | Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks |
title_sort | identifying membrane protein types based on lifelong learning with dynamically scalable networks |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964460/ https://www.ncbi.nlm.nih.gov/pubmed/35371189 http://dx.doi.org/10.3389/fgene.2021.834488 |
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