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Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks

Membrane proteins are an essential part of the body’s ability to maintain normal life activities. Further research into membrane proteins, which are present in all aspects of life science research, will help to advance the development of cells and drugs. The current methods for predicting proteins a...

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Autores principales: Lu, Weizhong, Shen, Jiawei, Zhang, Yu, Wu, Hongjie, Qian, Yuqing, Chen, Xiaoyi, Fu, Qiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964460/
https://www.ncbi.nlm.nih.gov/pubmed/35371189
http://dx.doi.org/10.3389/fgene.2021.834488
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author Lu, Weizhong
Shen, Jiawei
Zhang, Yu
Wu, Hongjie
Qian, Yuqing
Chen, Xiaoyi
Fu, Qiming
author_facet Lu, Weizhong
Shen, Jiawei
Zhang, Yu
Wu, Hongjie
Qian, Yuqing
Chen, Xiaoyi
Fu, Qiming
author_sort Lu, Weizhong
collection PubMed
description Membrane proteins are an essential part of the body’s ability to maintain normal life activities. Further research into membrane proteins, which are present in all aspects of life science research, will help to advance the development of cells and drugs. The current methods for predicting proteins are usually based on machine learning, but further improvements in prediction effectiveness and accuracy are needed. In this paper, we propose a dynamic deep network architecture based on lifelong learning in order to use computers to classify membrane proteins more effectively. The model extends the application area of lifelong learning and provides new ideas for multiple classification problems in bioinformatics. To demonstrate the performance of our model, we conducted experiments on top of two datasets and compared them with other classification methods. The results show that our model achieves high accuracy (95.3 and 93.5%) on benchmark datasets and is more effective compared to other methods.
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spelling pubmed-89644602022-03-31 Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks Lu, Weizhong Shen, Jiawei Zhang, Yu Wu, Hongjie Qian, Yuqing Chen, Xiaoyi Fu, Qiming Front Genet Genetics Membrane proteins are an essential part of the body’s ability to maintain normal life activities. Further research into membrane proteins, which are present in all aspects of life science research, will help to advance the development of cells and drugs. The current methods for predicting proteins are usually based on machine learning, but further improvements in prediction effectiveness and accuracy are needed. In this paper, we propose a dynamic deep network architecture based on lifelong learning in order to use computers to classify membrane proteins more effectively. The model extends the application area of lifelong learning and provides new ideas for multiple classification problems in bioinformatics. To demonstrate the performance of our model, we conducted experiments on top of two datasets and compared them with other classification methods. The results show that our model achieves high accuracy (95.3 and 93.5%) on benchmark datasets and is more effective compared to other methods. Frontiers Media S.A. 2022-03-14 /pmc/articles/PMC8964460/ /pubmed/35371189 http://dx.doi.org/10.3389/fgene.2021.834488 Text en Copyright © 2022 Lu, Shen, Zhang, Wu, Qian, Chen and Fu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Lu, Weizhong
Shen, Jiawei
Zhang, Yu
Wu, Hongjie
Qian, Yuqing
Chen, Xiaoyi
Fu, Qiming
Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks
title Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks
title_full Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks
title_fullStr Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks
title_full_unstemmed Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks
title_short Identifying Membrane Protein Types Based on Lifelong Learning With Dynamically Scalable Networks
title_sort identifying membrane protein types based on lifelong learning with dynamically scalable networks
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964460/
https://www.ncbi.nlm.nih.gov/pubmed/35371189
http://dx.doi.org/10.3389/fgene.2021.834488
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