Cargando…
Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis
BACKGROUND: Hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) is rare. The aim of this study is to evaluate the long-term prognosis of liver resection (LR) versus transcatheter arterial chemoembolization (TACE) in these patients. METHODS: Data from HCC patients with BDTT who underw...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964486/ https://www.ncbi.nlm.nih.gov/pubmed/35372001 http://dx.doi.org/10.3389/fonc.2022.835559 |
_version_ | 1784678230648684544 |
---|---|
author | Liu, Zong-Han Sun, Ju-Xian Feng, Jin-Kai Yang, Shi-Ye Chen, Zhen-Hua Liu, Chang Chai, Zong-Tao Mao, Fei-Fei Guo, Wei-Xing Shi, Jie Cheng, Shu-Qun |
author_facet | Liu, Zong-Han Sun, Ju-Xian Feng, Jin-Kai Yang, Shi-Ye Chen, Zhen-Hua Liu, Chang Chai, Zong-Tao Mao, Fei-Fei Guo, Wei-Xing Shi, Jie Cheng, Shu-Qun |
author_sort | Liu, Zong-Han |
collection | PubMed |
description | BACKGROUND: Hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) is rare. The aim of this study is to evaluate the long-term prognosis of liver resection (LR) versus transcatheter arterial chemoembolization (TACE) in these patients. METHODS: Data from HCC patients with BDTT who underwent liver resection and TACE were analyzed respectively. Propensity score matching (PSM) analysis was performed in these patients. RESULTS: A total of 145 HCC patients with BDTT were divided into two groups: the LR group (n = 105) and the TACE group (n = 40). The median OS in the LR group was 8.0 months longer than that in the TACE group before PSM (21.0 vs. 13.0 months, P <0.001) and 9.0 months longer after PSM (20.0 vs. 11.0 months, P <0.001). The median DFS in the LR group was 3.5 months longer than that in the TACE group before PSM (7.0 vs. 3.5 months, P = 0.007) and 5 months longer after PSM (7.0 vs. 2.0 months, P = 0.007). CONCLUSION: If surgery is technically feasible, liver resection provides better prognosis for HCC patients with BDTT compared with TACE. |
format | Online Article Text |
id | pubmed-8964486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89644862022-03-31 Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis Liu, Zong-Han Sun, Ju-Xian Feng, Jin-Kai Yang, Shi-Ye Chen, Zhen-Hua Liu, Chang Chai, Zong-Tao Mao, Fei-Fei Guo, Wei-Xing Shi, Jie Cheng, Shu-Qun Front Oncol Oncology BACKGROUND: Hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) is rare. The aim of this study is to evaluate the long-term prognosis of liver resection (LR) versus transcatheter arterial chemoembolization (TACE) in these patients. METHODS: Data from HCC patients with BDTT who underwent liver resection and TACE were analyzed respectively. Propensity score matching (PSM) analysis was performed in these patients. RESULTS: A total of 145 HCC patients with BDTT were divided into two groups: the LR group (n = 105) and the TACE group (n = 40). The median OS in the LR group was 8.0 months longer than that in the TACE group before PSM (21.0 vs. 13.0 months, P <0.001) and 9.0 months longer after PSM (20.0 vs. 11.0 months, P <0.001). The median DFS in the LR group was 3.5 months longer than that in the TACE group before PSM (7.0 vs. 3.5 months, P = 0.007) and 5 months longer after PSM (7.0 vs. 2.0 months, P = 0.007). CONCLUSION: If surgery is technically feasible, liver resection provides better prognosis for HCC patients with BDTT compared with TACE. Frontiers Media S.A. 2022-03-15 /pmc/articles/PMC8964486/ /pubmed/35372001 http://dx.doi.org/10.3389/fonc.2022.835559 Text en Copyright © 2022 Liu, Sun, Feng, Yang, Chen, Liu, Chai, Mao, Guo, Shi and Cheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Liu, Zong-Han Sun, Ju-Xian Feng, Jin-Kai Yang, Shi-Ye Chen, Zhen-Hua Liu, Chang Chai, Zong-Tao Mao, Fei-Fei Guo, Wei-Xing Shi, Jie Cheng, Shu-Qun Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis |
title | Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis |
title_full | Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis |
title_fullStr | Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis |
title_full_unstemmed | Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis |
title_short | Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis |
title_sort | prognostic comparison between liver resection and transcatheter arterial chemoembolization for hepatocellular carcinoma patients with bile duct tumor thrombus: a propensity-score matching analysis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964486/ https://www.ncbi.nlm.nih.gov/pubmed/35372001 http://dx.doi.org/10.3389/fonc.2022.835559 |
work_keys_str_mv | AT liuzonghan prognosticcomparisonbetweenliverresectionandtranscatheterarterialchemoembolizationforhepatocellularcarcinomapatientswithbileducttumorthrombusapropensityscorematchinganalysis AT sunjuxian prognosticcomparisonbetweenliverresectionandtranscatheterarterialchemoembolizationforhepatocellularcarcinomapatientswithbileducttumorthrombusapropensityscorematchinganalysis AT fengjinkai prognosticcomparisonbetweenliverresectionandtranscatheterarterialchemoembolizationforhepatocellularcarcinomapatientswithbileducttumorthrombusapropensityscorematchinganalysis AT yangshiye prognosticcomparisonbetweenliverresectionandtranscatheterarterialchemoembolizationforhepatocellularcarcinomapatientswithbileducttumorthrombusapropensityscorematchinganalysis AT chenzhenhua prognosticcomparisonbetweenliverresectionandtranscatheterarterialchemoembolizationforhepatocellularcarcinomapatientswithbileducttumorthrombusapropensityscorematchinganalysis AT liuchang prognosticcomparisonbetweenliverresectionandtranscatheterarterialchemoembolizationforhepatocellularcarcinomapatientswithbileducttumorthrombusapropensityscorematchinganalysis AT chaizongtao prognosticcomparisonbetweenliverresectionandtranscatheterarterialchemoembolizationforhepatocellularcarcinomapatientswithbileducttumorthrombusapropensityscorematchinganalysis AT maofeifei prognosticcomparisonbetweenliverresectionandtranscatheterarterialchemoembolizationforhepatocellularcarcinomapatientswithbileducttumorthrombusapropensityscorematchinganalysis AT guoweixing prognosticcomparisonbetweenliverresectionandtranscatheterarterialchemoembolizationforhepatocellularcarcinomapatientswithbileducttumorthrombusapropensityscorematchinganalysis AT shijie prognosticcomparisonbetweenliverresectionandtranscatheterarterialchemoembolizationforhepatocellularcarcinomapatientswithbileducttumorthrombusapropensityscorematchinganalysis AT chengshuqun prognosticcomparisonbetweenliverresectionandtranscatheterarterialchemoembolizationforhepatocellularcarcinomapatientswithbileducttumorthrombusapropensityscorematchinganalysis |