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Brain Functional Connectivity in de novo Parkinson's Disease Patients Based on Clinical EEG

In Parkinson's disease (PD), cortical–subcortical interplay plays a relevant role in affecting clinical performance. Functional MRI sequences described changes in functional connectivity at different stages of disease. Scarce are, instead, the investigations examining brain connectivity in pati...

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Autores principales: Conti, Matteo, Bovenzi, Roberta, Garasto, Elena, Schirinzi, Tommaso, Placidi, Fabio, Mercuri, Nicola B., Cerroni, Rocco, Pierantozzi, Mariangela, Stefani, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964594/
https://www.ncbi.nlm.nih.gov/pubmed/35370899
http://dx.doi.org/10.3389/fneur.2022.844745
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author Conti, Matteo
Bovenzi, Roberta
Garasto, Elena
Schirinzi, Tommaso
Placidi, Fabio
Mercuri, Nicola B.
Cerroni, Rocco
Pierantozzi, Mariangela
Stefani, Alessandro
author_facet Conti, Matteo
Bovenzi, Roberta
Garasto, Elena
Schirinzi, Tommaso
Placidi, Fabio
Mercuri, Nicola B.
Cerroni, Rocco
Pierantozzi, Mariangela
Stefani, Alessandro
author_sort Conti, Matteo
collection PubMed
description In Parkinson's disease (PD), cortical–subcortical interplay plays a relevant role in affecting clinical performance. Functional MRI sequences described changes in functional connectivity at different stages of disease. Scarce are, instead, the investigations examining brain connectivity in patients with PD at early stages of disease. For this aim, here we analyzed the differences in functional connectivity between de novo, never treated, PD patients and healthy controls. The analyses were based upon custom-written scripts on the Matlab platform, combined with high-level functions of Fieldtrip, Brainstorm, and Brain Connectivity toolboxes. First, we proceeded to the spectral analysis of the EEG data in the five frequency bands (δ-θ-α-β-γ). Second, we calculated functional connectivity matrices based on both coherency (COH) and imaginary part of coherency (iCOH), in the δ-θ-α-β-γ frequency bands. Then, four network measures (density, transitivity, global efficiency, and assortativity) were computed in identified connectivity matrices. Finally, we compared the spectral density, functional connectivity matrices, and network measured between healthy controls and de novo PD patients through two-samples T-test. A total of 21 de novo PD patients and 20 healthy subjects were studied. No differences were observed in spectral analysis between the two groups, with the exception of the γ band where a significant increase in power density was found in PD patients. A reduced connectivity in the main EEG frequency bands (α-β frequency bands) was observed in PD patients compared to controls, while a hyperconnectivity was found in PD patients in γ band. Among the network measures, a reduced assortativity coefficient was found in de novo PD patients in α frequency band. Our results show the occurrence of early EEG functional connectivity alterations from the initial stages of PD. From this point of view, connectivity analysis may ease a better understanding of the complexity of PD physiopathology.
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spelling pubmed-89645942022-03-31 Brain Functional Connectivity in de novo Parkinson's Disease Patients Based on Clinical EEG Conti, Matteo Bovenzi, Roberta Garasto, Elena Schirinzi, Tommaso Placidi, Fabio Mercuri, Nicola B. Cerroni, Rocco Pierantozzi, Mariangela Stefani, Alessandro Front Neurol Neurology In Parkinson's disease (PD), cortical–subcortical interplay plays a relevant role in affecting clinical performance. Functional MRI sequences described changes in functional connectivity at different stages of disease. Scarce are, instead, the investigations examining brain connectivity in patients with PD at early stages of disease. For this aim, here we analyzed the differences in functional connectivity between de novo, never treated, PD patients and healthy controls. The analyses were based upon custom-written scripts on the Matlab platform, combined with high-level functions of Fieldtrip, Brainstorm, and Brain Connectivity toolboxes. First, we proceeded to the spectral analysis of the EEG data in the five frequency bands (δ-θ-α-β-γ). Second, we calculated functional connectivity matrices based on both coherency (COH) and imaginary part of coherency (iCOH), in the δ-θ-α-β-γ frequency bands. Then, four network measures (density, transitivity, global efficiency, and assortativity) were computed in identified connectivity matrices. Finally, we compared the spectral density, functional connectivity matrices, and network measured between healthy controls and de novo PD patients through two-samples T-test. A total of 21 de novo PD patients and 20 healthy subjects were studied. No differences were observed in spectral analysis between the two groups, with the exception of the γ band where a significant increase in power density was found in PD patients. A reduced connectivity in the main EEG frequency bands (α-β frequency bands) was observed in PD patients compared to controls, while a hyperconnectivity was found in PD patients in γ band. Among the network measures, a reduced assortativity coefficient was found in de novo PD patients in α frequency band. Our results show the occurrence of early EEG functional connectivity alterations from the initial stages of PD. From this point of view, connectivity analysis may ease a better understanding of the complexity of PD physiopathology. Frontiers Media S.A. 2022-03-15 /pmc/articles/PMC8964594/ /pubmed/35370899 http://dx.doi.org/10.3389/fneur.2022.844745 Text en Copyright © 2022 Conti, Bovenzi, Garasto, Schirinzi, Placidi, Mercuri, Cerroni, Pierantozzi and Stefani. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Conti, Matteo
Bovenzi, Roberta
Garasto, Elena
Schirinzi, Tommaso
Placidi, Fabio
Mercuri, Nicola B.
Cerroni, Rocco
Pierantozzi, Mariangela
Stefani, Alessandro
Brain Functional Connectivity in de novo Parkinson's Disease Patients Based on Clinical EEG
title Brain Functional Connectivity in de novo Parkinson's Disease Patients Based on Clinical EEG
title_full Brain Functional Connectivity in de novo Parkinson's Disease Patients Based on Clinical EEG
title_fullStr Brain Functional Connectivity in de novo Parkinson's Disease Patients Based on Clinical EEG
title_full_unstemmed Brain Functional Connectivity in de novo Parkinson's Disease Patients Based on Clinical EEG
title_short Brain Functional Connectivity in de novo Parkinson's Disease Patients Based on Clinical EEG
title_sort brain functional connectivity in de novo parkinson's disease patients based on clinical eeg
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964594/
https://www.ncbi.nlm.nih.gov/pubmed/35370899
http://dx.doi.org/10.3389/fneur.2022.844745
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