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Allosteric modulation of dopamine D(2L) receptor in complex with G(i1) and G(i2) proteins: the effect of subtle structural and stereochemical ligand modifications

BACKGROUND: Allosteric modulation of G protein-coupled receptors (GPCRs) is nowadays one of the hot topics in drug discovery. In particular, allosteric modulators of D(2) receptor have been proposed as potential modern therapeutics to treat schizophrenia and Parkinson’s disease. METHODS: To address...

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Detalles Bibliográficos
Autores principales:	Żuk, Justyna, Bartuzi, Damian, Silva, Andrea G., Pitucha, Monika, Koszła, Oliwia, Wróbel, Tomasz M., Matosiuk, Dariusz, Castro, Marián, Kaczor, Agnieszka A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964653/ https://www.ncbi.nlm.nih.gov/pubmed/35064921 http://dx.doi.org/10.1007/s43440-021-00352-x

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