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Selected transgenic murine models of human autoimmune liver diseases
Murine models of human diseases are of outmost importance for both studying molecular mechanisms driving their development and testing new treatment strategies. In this review, we first discuss the etiology and risk factors for autoimmune liver disease, including primary biliary cholangitis, autoimm...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964654/ https://www.ncbi.nlm.nih.gov/pubmed/35032321 http://dx.doi.org/10.1007/s43440-021-00351-y |
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author | Trzos, Katarzyna Pydyn, Natalia Jura, Jolanta Kotlinowski, Jerzy |
author_facet | Trzos, Katarzyna Pydyn, Natalia Jura, Jolanta Kotlinowski, Jerzy |
author_sort | Trzos, Katarzyna |
collection | PubMed |
description | Murine models of human diseases are of outmost importance for both studying molecular mechanisms driving their development and testing new treatment strategies. In this review, we first discuss the etiology and risk factors for autoimmune liver disease, including primary biliary cholangitis, autoimmune hepatitis and primary sclerosing cholangitis. Second, we highlight important features of murine transgenic models that make them useful for basic scientists, drug developers and clinical researchers. Next, a brief description of each disease is followed by the characterization of selected animal models. |
format | Online Article Text |
id | pubmed-8964654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-89646542022-04-07 Selected transgenic murine models of human autoimmune liver diseases Trzos, Katarzyna Pydyn, Natalia Jura, Jolanta Kotlinowski, Jerzy Pharmacol Rep Review Murine models of human diseases are of outmost importance for both studying molecular mechanisms driving their development and testing new treatment strategies. In this review, we first discuss the etiology and risk factors for autoimmune liver disease, including primary biliary cholangitis, autoimmune hepatitis and primary sclerosing cholangitis. Second, we highlight important features of murine transgenic models that make them useful for basic scientists, drug developers and clinical researchers. Next, a brief description of each disease is followed by the characterization of selected animal models. Springer International Publishing 2022-01-15 2022 /pmc/articles/PMC8964654/ /pubmed/35032321 http://dx.doi.org/10.1007/s43440-021-00351-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Trzos, Katarzyna Pydyn, Natalia Jura, Jolanta Kotlinowski, Jerzy Selected transgenic murine models of human autoimmune liver diseases |
title | Selected transgenic murine models of human autoimmune liver diseases |
title_full | Selected transgenic murine models of human autoimmune liver diseases |
title_fullStr | Selected transgenic murine models of human autoimmune liver diseases |
title_full_unstemmed | Selected transgenic murine models of human autoimmune liver diseases |
title_short | Selected transgenic murine models of human autoimmune liver diseases |
title_sort | selected transgenic murine models of human autoimmune liver diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964654/ https://www.ncbi.nlm.nih.gov/pubmed/35032321 http://dx.doi.org/10.1007/s43440-021-00351-y |
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