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Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization
Species-specific differences control cancer risk across orders of magnitude variation in body size and lifespan, e.g., by varying the copy numbers of tumor suppressor genes. It is unclear, however, how different tissues within an organism can control somatic evolution despite being subject to marked...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964737/ https://www.ncbi.nlm.nih.gov/pubmed/35351889 http://dx.doi.org/10.1038/s41467-022-29004-1 |