Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling

The identification and validation of a small molecule’s targets is a major bottleneck in the discovery process for tuberculosis antibiotics. Activity-based protein profiling (ABPP) is an efficient tool for determining a small molecule’s targets within complex proteomes. However, how target inhibitio...

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Detalles Bibliográficos
Autores principales: Li, Michael, Patel, Hiren V., Cognetta, Armand B., Smith, Trever C., Mallick, Ivy, Cavalier, Jean-François, Previti, Mary L., Canaan, Stéphane, Aldridge, Bree B., Cravatt, Benjamin F., Seeliger, Jessica C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964833/
https://www.ncbi.nlm.nih.gov/pubmed/34599873
http://dx.doi.org/10.1016/j.chembiol.2021.09.002

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