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The Prognostic Impact of Tumor Location in pT3N0M0 Upper Urinary Tract Urothelial Carcinoma: A Retrospective Cohort Study

BACKGROUND: We aimed to evaluate the impact of tumor location on cancer outcomes in patients with pT3N0M0 upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU) with bladder cuff excision. MATERIALS AND METHODS: We retrospectively reviewed 302 patients with pT3N0M0 UTU...

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Autores principales: Chen, Tzu Shuang, Chen, Yen Ta, Wang, Hung Jen, Chiang, Po Hui, Yang, Wen Chou, Lee, Wei Ching, Chuang, Yao Chi, Cheng, Yuan Tso, Kang, Chih Hsiung, Lee, Wei Chia, Chen, Chien Hsu, Shen, Yuan Chi, Liu, Yi Yang, Liu, Hui Ying, Chang, Yin Lun, Su, Yu Li, Huang, Chun Chieh, Luo, Hao Lun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964942/
https://www.ncbi.nlm.nih.gov/pubmed/35372015
http://dx.doi.org/10.3389/fonc.2022.850874
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author Chen, Tzu Shuang
Chen, Yen Ta
Wang, Hung Jen
Chiang, Po Hui
Yang, Wen Chou
Lee, Wei Ching
Chuang, Yao Chi
Cheng, Yuan Tso
Kang, Chih Hsiung
Lee, Wei Chia
Chen, Chien Hsu
Shen, Yuan Chi
Liu, Yi Yang
Liu, Hui Ying
Chang, Yin Lun
Su, Yu Li
Huang, Chun Chieh
Luo, Hao Lun
author_facet Chen, Tzu Shuang
Chen, Yen Ta
Wang, Hung Jen
Chiang, Po Hui
Yang, Wen Chou
Lee, Wei Ching
Chuang, Yao Chi
Cheng, Yuan Tso
Kang, Chih Hsiung
Lee, Wei Chia
Chen, Chien Hsu
Shen, Yuan Chi
Liu, Yi Yang
Liu, Hui Ying
Chang, Yin Lun
Su, Yu Li
Huang, Chun Chieh
Luo, Hao Lun
author_sort Chen, Tzu Shuang
collection PubMed
description BACKGROUND: We aimed to evaluate the impact of tumor location on cancer outcomes in patients with pT3N0M0 upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU) with bladder cuff excision. MATERIALS AND METHODS: We retrospectively reviewed 302 patients with pT3N0M0 UTUC who underwent RNU with bladder cuff excision at our institution between 2005 and 2019, including 191 renal pelvis tumors and 111 ureteral tumors. Clinicopathologic characteristics were compared between renal pelvis and ureter urothelial carcinomas. Multivariate Cox proportional hazard regression was used to assess the association between outcomes and clinical factors. Outcomes of interest included intravesical recurrence-free survival (IVRFS), local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and cancer-specific survival (CSS), which were measured using the Kaplan–Meier curve with a log-rank test. RESULTS: A total of 302 patients underwent RNU with bladder cuff excision. During the median follow-up of 42.7 months, 70 (23.2%), 95 (31.5%), and 99 (32.8%) patients experienced intravesical recurrence, local recurrence, and distant metastasis, respectively. Seventy (23.2%) patients died from UTUC. Multivariate Cox regression analysis showed that tumor location was an independent predictor of local recurrence (HR = 2.05, p = 0.001), with borderline independent significance in intravesical recurrence (HR = 1.54, p = 0.074) and distant metastasis (HR = 1.45, p = 0.08). Kaplan–Meier analysis showed that ureter tumors had a worse 5-year local recurrence (log-rank p < 0.001) and borderline worse 5-year intravesical recurrence (log-rank p = 0.055) and 5-year distant metastasis (log-rank p = 0.073). CONCLUSION: Ureter tumors seem to be associated with worse oncological outcomes, especially with local recurrence in UTUC. Further large and long-term studies are warranted for investigating biological differences based on tumor location.
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spelling pubmed-89649422022-03-31 The Prognostic Impact of Tumor Location in pT3N0M0 Upper Urinary Tract Urothelial Carcinoma: A Retrospective Cohort Study Chen, Tzu Shuang Chen, Yen Ta Wang, Hung Jen Chiang, Po Hui Yang, Wen Chou Lee, Wei Ching Chuang, Yao Chi Cheng, Yuan Tso Kang, Chih Hsiung Lee, Wei Chia Chen, Chien Hsu Shen, Yuan Chi Liu, Yi Yang Liu, Hui Ying Chang, Yin Lun Su, Yu Li Huang, Chun Chieh Luo, Hao Lun Front Oncol Oncology BACKGROUND: We aimed to evaluate the impact of tumor location on cancer outcomes in patients with pT3N0M0 upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU) with bladder cuff excision. MATERIALS AND METHODS: We retrospectively reviewed 302 patients with pT3N0M0 UTUC who underwent RNU with bladder cuff excision at our institution between 2005 and 2019, including 191 renal pelvis tumors and 111 ureteral tumors. Clinicopathologic characteristics were compared between renal pelvis and ureter urothelial carcinomas. Multivariate Cox proportional hazard regression was used to assess the association between outcomes and clinical factors. Outcomes of interest included intravesical recurrence-free survival (IVRFS), local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and cancer-specific survival (CSS), which were measured using the Kaplan–Meier curve with a log-rank test. RESULTS: A total of 302 patients underwent RNU with bladder cuff excision. During the median follow-up of 42.7 months, 70 (23.2%), 95 (31.5%), and 99 (32.8%) patients experienced intravesical recurrence, local recurrence, and distant metastasis, respectively. Seventy (23.2%) patients died from UTUC. Multivariate Cox regression analysis showed that tumor location was an independent predictor of local recurrence (HR = 2.05, p = 0.001), with borderline independent significance in intravesical recurrence (HR = 1.54, p = 0.074) and distant metastasis (HR = 1.45, p = 0.08). Kaplan–Meier analysis showed that ureter tumors had a worse 5-year local recurrence (log-rank p < 0.001) and borderline worse 5-year intravesical recurrence (log-rank p = 0.055) and 5-year distant metastasis (log-rank p = 0.073). CONCLUSION: Ureter tumors seem to be associated with worse oncological outcomes, especially with local recurrence in UTUC. Further large and long-term studies are warranted for investigating biological differences based on tumor location. Frontiers Media S.A. 2022-03-15 /pmc/articles/PMC8964942/ /pubmed/35372015 http://dx.doi.org/10.3389/fonc.2022.850874 Text en Copyright © 2022 Chen, Chen, Wang, Chiang, Yang, Lee, Chuang, Cheng, Kang, Lee, Chen, Shen, Liu, Liu, Chang, Su, Huang and Luo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Tzu Shuang
Chen, Yen Ta
Wang, Hung Jen
Chiang, Po Hui
Yang, Wen Chou
Lee, Wei Ching
Chuang, Yao Chi
Cheng, Yuan Tso
Kang, Chih Hsiung
Lee, Wei Chia
Chen, Chien Hsu
Shen, Yuan Chi
Liu, Yi Yang
Liu, Hui Ying
Chang, Yin Lun
Su, Yu Li
Huang, Chun Chieh
Luo, Hao Lun
The Prognostic Impact of Tumor Location in pT3N0M0 Upper Urinary Tract Urothelial Carcinoma: A Retrospective Cohort Study
title The Prognostic Impact of Tumor Location in pT3N0M0 Upper Urinary Tract Urothelial Carcinoma: A Retrospective Cohort Study
title_full The Prognostic Impact of Tumor Location in pT3N0M0 Upper Urinary Tract Urothelial Carcinoma: A Retrospective Cohort Study
title_fullStr The Prognostic Impact of Tumor Location in pT3N0M0 Upper Urinary Tract Urothelial Carcinoma: A Retrospective Cohort Study
title_full_unstemmed The Prognostic Impact of Tumor Location in pT3N0M0 Upper Urinary Tract Urothelial Carcinoma: A Retrospective Cohort Study
title_short The Prognostic Impact of Tumor Location in pT3N0M0 Upper Urinary Tract Urothelial Carcinoma: A Retrospective Cohort Study
title_sort prognostic impact of tumor location in pt3n0m0 upper urinary tract urothelial carcinoma: a retrospective cohort study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964942/
https://www.ncbi.nlm.nih.gov/pubmed/35372015
http://dx.doi.org/10.3389/fonc.2022.850874
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