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Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression?

Several serine proteases have been linked to autoimmune disorders and tumour initiation although the mechanisms are not fully understood. Activation of the kynurenine pathway enzyme indoleamine-2,3-dioxygenase (IDO1) modulates cellular activity in the brain, tolerogenesis in the immune system and is...

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Detalles Bibliográficos
Autores principales:	Clanchy, Felix I. L., Huang, Yi-Shu, Ogbechi, Joy, Darlington, L. Gail, Williams, Richard O., Stone, Trevor W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964980/ https://www.ncbi.nlm.nih.gov/pubmed/35371018 http://dx.doi.org/10.3389/fimmu.2022.832989

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