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Investigation of Allergic Sensitizations in Children With Allergic Rhinitis and/or Asthma

OBJECTIVE: Allergic rhinitis (AR) and asthma are becoming one of the most prevalent diseases in children. Identifying sensitization to aeroallergens is seemed to be valuable for diagnosing allergic disease and guiding its treatment. This study aimed to analyze the profiles of sensitization to aeroal...

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Autores principales: Dai, Lingman, Liu, Jinling, Zhao, Qi, Li, Mengyao, Zhou, Yunlian, Chen, Zhimin, Zhang, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964996/
https://www.ncbi.nlm.nih.gov/pubmed/35372139
http://dx.doi.org/10.3389/fped.2022.842293
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author Dai, Lingman
Liu, Jinling
Zhao, Qi
Li, Mengyao
Zhou, Yunlian
Chen, Zhimin
Zhang, Yuanyuan
author_facet Dai, Lingman
Liu, Jinling
Zhao, Qi
Li, Mengyao
Zhou, Yunlian
Chen, Zhimin
Zhang, Yuanyuan
author_sort Dai, Lingman
collection PubMed
description OBJECTIVE: Allergic rhinitis (AR) and asthma are becoming one of the most prevalent diseases in children. Identifying sensitization to aeroallergens is seemed to be valuable for diagnosing allergic disease and guiding its treatment. This study aimed to analyze the profiles of sensitization to aeroallergen in children with AR and/or asthma by skin prick test (SPT) and explore the differences of sensitization between different kinds of allergic diseases, different sexes, and different ages. METHODS: A total of 230 children with AR and/or asthma who were hospitalized in our hospital from June 2017 to September 2019 were eligible in this retrospective study. All patients completed standardized questionnaires and SPT. Based on the sex, age, or classification of allergic disease, the sensitizations to 13 aeroallergens were compared. RESULTS: Of the 230 patients, 67.4% of enrolled were positive for SPT; the top 5 allergens were Dermatophagoides pteronyssinus (Der.p) (59.3%), Dermatophagoides farina (Der.f ) (58.7%), Blomia tropicalis (Blot.) (40.3%), dog hair (36.1%), and Blattella germanica (20.4%). More than 90% of patients were sensitized to two or more allergens. As to the effect of age on aeroallergens, we found that the sensitizations of Blot., dog fur, and multiple sensitizations (≥5 allergens) were more common in adolescence (P < 0.01, P < 0.05). Regarding sex, we found that the positive rate of SPT and the percentages of double-allergen sensitizations in boys were much higher than girls (P < 0.01, P < 0.01), and the positive rate to Der.p, Der.f , and ragweed were also significantly higher in boys (P < 0.01, P < 0.05, and P < 0.05, respectively). Furthermore, we found that asthma–rhinitis multimorbidity increased the incidences of sensitizations; patients with AR and asthma had significantly higher positive rates to Der.p and Der.f when compared with the AR or asthma group (P < 0.05, P < 0.05). CONCLUSION: Allergic sensitizations were common in children with AR and/or asthma; sex, age, and asthma–rhinitis multimorbidity might affect the prevalence of sensitizations to aeroallergens.
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spelling pubmed-89649962022-03-31 Investigation of Allergic Sensitizations in Children With Allergic Rhinitis and/or Asthma Dai, Lingman Liu, Jinling Zhao, Qi Li, Mengyao Zhou, Yunlian Chen, Zhimin Zhang, Yuanyuan Front Pediatr Pediatrics OBJECTIVE: Allergic rhinitis (AR) and asthma are becoming one of the most prevalent diseases in children. Identifying sensitization to aeroallergens is seemed to be valuable for diagnosing allergic disease and guiding its treatment. This study aimed to analyze the profiles of sensitization to aeroallergen in children with AR and/or asthma by skin prick test (SPT) and explore the differences of sensitization between different kinds of allergic diseases, different sexes, and different ages. METHODS: A total of 230 children with AR and/or asthma who were hospitalized in our hospital from June 2017 to September 2019 were eligible in this retrospective study. All patients completed standardized questionnaires and SPT. Based on the sex, age, or classification of allergic disease, the sensitizations to 13 aeroallergens were compared. RESULTS: Of the 230 patients, 67.4% of enrolled were positive for SPT; the top 5 allergens were Dermatophagoides pteronyssinus (Der.p) (59.3%), Dermatophagoides farina (Der.f ) (58.7%), Blomia tropicalis (Blot.) (40.3%), dog hair (36.1%), and Blattella germanica (20.4%). More than 90% of patients were sensitized to two or more allergens. As to the effect of age on aeroallergens, we found that the sensitizations of Blot., dog fur, and multiple sensitizations (≥5 allergens) were more common in adolescence (P < 0.01, P < 0.05). Regarding sex, we found that the positive rate of SPT and the percentages of double-allergen sensitizations in boys were much higher than girls (P < 0.01, P < 0.01), and the positive rate to Der.p, Der.f , and ragweed were also significantly higher in boys (P < 0.01, P < 0.05, and P < 0.05, respectively). Furthermore, we found that asthma–rhinitis multimorbidity increased the incidences of sensitizations; patients with AR and asthma had significantly higher positive rates to Der.p and Der.f when compared with the AR or asthma group (P < 0.05, P < 0.05). CONCLUSION: Allergic sensitizations were common in children with AR and/or asthma; sex, age, and asthma–rhinitis multimorbidity might affect the prevalence of sensitizations to aeroallergens. Frontiers Media S.A. 2022-03-15 /pmc/articles/PMC8964996/ /pubmed/35372139 http://dx.doi.org/10.3389/fped.2022.842293 Text en Copyright © 2022 Dai, Liu, Zhao, Li, Zhou, Chen and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Dai, Lingman
Liu, Jinling
Zhao, Qi
Li, Mengyao
Zhou, Yunlian
Chen, Zhimin
Zhang, Yuanyuan
Investigation of Allergic Sensitizations in Children With Allergic Rhinitis and/or Asthma
title Investigation of Allergic Sensitizations in Children With Allergic Rhinitis and/or Asthma
title_full Investigation of Allergic Sensitizations in Children With Allergic Rhinitis and/or Asthma
title_fullStr Investigation of Allergic Sensitizations in Children With Allergic Rhinitis and/or Asthma
title_full_unstemmed Investigation of Allergic Sensitizations in Children With Allergic Rhinitis and/or Asthma
title_short Investigation of Allergic Sensitizations in Children With Allergic Rhinitis and/or Asthma
title_sort investigation of allergic sensitizations in children with allergic rhinitis and/or asthma
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964996/
https://www.ncbi.nlm.nih.gov/pubmed/35372139
http://dx.doi.org/10.3389/fped.2022.842293
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