Inhibition of Histone H3 Lysine-27 Demethylase Activity Relieves Rheumatoid Arthritis Symptoms via Repression of IL6 Transcription in Macrophages

Rheumatoid arthritis (RA) occurs in about 5 per 1,000 people and can lead to severe joint damage and disability. However, the knowledge of pathogenesis and treatment for RA remains limited. Here, we found that histone demethylase inhibitor GSK-J4 relieved collagen induced arthritis (CIA) symptom in...

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Detalles Bibliográficos
Autores principales: Zhao, Zhan, Zhang, Yazhuo, Gao, Danling, Zhang, Yidan, Han, Wenwei, Xu, Ximing, Song, Qiaoling, Zhao, Chenyang, Yang, Jinbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965057/
https://www.ncbi.nlm.nih.gov/pubmed/35371061
http://dx.doi.org/10.3389/fimmu.2022.818070

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