Intra-S phase checkpoint kinase Chk1 dissociates replication proteins Treslin and TopBP1 through multiple mechanisms during replication stress

Replication stress impedes DNA polymerase progression causing activation of the ataxia telangiectasia and Rad3-related signaling pathway, which promotes the intra-S phase checkpoint activity through phosphorylation of checkpoint kinase 1 (Chk1). Chk1 suppresses replication origin firing, in part, by...

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Detalles Bibliográficos
Autores principales: Kelly, Rebecca L., Huehls, Amelia M., Venkatachalam, Annapoorna, Huntoon, Catherine J., Machida, Yuichi J., Karnitz, Larry M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965152/
https://www.ncbi.nlm.nih.gov/pubmed/35231445
http://dx.doi.org/10.1016/j.jbc.2022.101777

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