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Surgical management options for long-bone metastasis

Bone metastases are difficult to treat surgically, necessitating a multidisciplinary approach that must be applied to each patient depending on the specifics of their case. The main indications for surgical treatment are a lack of response to chemotherapy, radiation therapy, hormone therapy, immunot...

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Autores principales: Cirstoiu, Catalin, Cretu, Bogdan, Iordache, Sergiu, Popa, Mihnea, Serban, Bogdan, Cursaru, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965201/
https://www.ncbi.nlm.nih.gov/pubmed/35298408
http://dx.doi.org/10.1530/EOR-21-0119
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author Cirstoiu, Catalin
Cretu, Bogdan
Iordache, Sergiu
Popa, Mihnea
Serban, Bogdan
Cursaru, Adrian
author_facet Cirstoiu, Catalin
Cretu, Bogdan
Iordache, Sergiu
Popa, Mihnea
Serban, Bogdan
Cursaru, Adrian
author_sort Cirstoiu, Catalin
collection PubMed
description Bone metastases are difficult to treat surgically, necessitating a multidisciplinary approach that must be applied to each patient depending on the specifics of their case. The main indications for surgical treatment are a lack of response to chemotherapy, radiation therapy, hormone therapy, immunotherapy, and bisphosphonates which is defined by persistent pain or tumor progression; the risk of imminent pathological bone fracture; and surgical treatment for single bone metastases. An important aspect of choosing the right treatment for these patients is accurately estimating life expectancy. Improved chemotherapy, postoperative radiation therapy, and sustainable reconstructive modalities will increase the patient’s life expectancy. The surgeon should select the best surgical strategy based on the primary tumor and its characteristics, the presence of single or multiple metastases, age, anatomical location, and the functional resources of the patient. Preventive osteosynthesis, osteosynthesis to stabilize a fracture, resections, and reconstructions are the main surgical options for bone metastases. Resection and reconstruction with a modular prosthesis remain the generally approved surgical option to restore functionality, increase the quality of life, and increase life expectancy. Preoperative embolization is necessary, especially in the case of metastases of renal or thyroid origin. This procedure is extremely important to avoid complications, with a major impact on survival rates.
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spelling pubmed-89652012022-03-30 Surgical management options for long-bone metastasis Cirstoiu, Catalin Cretu, Bogdan Iordache, Sergiu Popa, Mihnea Serban, Bogdan Cursaru, Adrian EFORT Open Rev Oncology Bone metastases are difficult to treat surgically, necessitating a multidisciplinary approach that must be applied to each patient depending on the specifics of their case. The main indications for surgical treatment are a lack of response to chemotherapy, radiation therapy, hormone therapy, immunotherapy, and bisphosphonates which is defined by persistent pain or tumor progression; the risk of imminent pathological bone fracture; and surgical treatment for single bone metastases. An important aspect of choosing the right treatment for these patients is accurately estimating life expectancy. Improved chemotherapy, postoperative radiation therapy, and sustainable reconstructive modalities will increase the patient’s life expectancy. The surgeon should select the best surgical strategy based on the primary tumor and its characteristics, the presence of single or multiple metastases, age, anatomical location, and the functional resources of the patient. Preventive osteosynthesis, osteosynthesis to stabilize a fracture, resections, and reconstructions are the main surgical options for bone metastases. Resection and reconstruction with a modular prosthesis remain the generally approved surgical option to restore functionality, increase the quality of life, and increase life expectancy. Preoperative embolization is necessary, especially in the case of metastases of renal or thyroid origin. This procedure is extremely important to avoid complications, with a major impact on survival rates. Bioscientifica Ltd 2022-03-17 /pmc/articles/PMC8965201/ /pubmed/35298408 http://dx.doi.org/10.1530/EOR-21-0119 Text en © The authors https://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Oncology
Cirstoiu, Catalin
Cretu, Bogdan
Iordache, Sergiu
Popa, Mihnea
Serban, Bogdan
Cursaru, Adrian
Surgical management options for long-bone metastasis
title Surgical management options for long-bone metastasis
title_full Surgical management options for long-bone metastasis
title_fullStr Surgical management options for long-bone metastasis
title_full_unstemmed Surgical management options for long-bone metastasis
title_short Surgical management options for long-bone metastasis
title_sort surgical management options for long-bone metastasis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965201/
https://www.ncbi.nlm.nih.gov/pubmed/35298408
http://dx.doi.org/10.1530/EOR-21-0119
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