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Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats

BACKGROUND: Lymphoma is the most common spinal cord neoplasm and second most common intracranial tumor in cats, but description of specific magnetic resonance imaging (MRI) features is lacking. OBJECTIVE: Describe the clinical and MRI features of lymphoma affecting the central (CNS) or peripheral (P...

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Autores principales: Durand, Alexane, Keenihan, Erin, Schweizer, Daniela, Maiolini, Arianna, Guevar, Julien, Oevermann, Anna, Gutierrez‐Quintana, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965233/
https://www.ncbi.nlm.nih.gov/pubmed/35048412
http://dx.doi.org/10.1111/jvim.16350
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author Durand, Alexane
Keenihan, Erin
Schweizer, Daniela
Maiolini, Arianna
Guevar, Julien
Oevermann, Anna
Gutierrez‐Quintana, Rodrigo
author_facet Durand, Alexane
Keenihan, Erin
Schweizer, Daniela
Maiolini, Arianna
Guevar, Julien
Oevermann, Anna
Gutierrez‐Quintana, Rodrigo
author_sort Durand, Alexane
collection PubMed
description BACKGROUND: Lymphoma is the most common spinal cord neoplasm and second most common intracranial tumor in cats, but description of specific magnetic resonance imaging (MRI) features is lacking. OBJECTIVE: Describe the clinical and MRI features of lymphoma affecting the central (CNS) or peripheral (PNS) nervous system or both in cats. ANIMALS: Thirty‐one cats with confirmed cytological or histopathological diagnosis or both of lymphoma involving the CNS or PNS or both, and MRI findings of the lesions. METHODS: Multicenter retrospective descriptive study. Signalment and medical information were recorded. Magnetic resonance imaging findings were reviewed by 3 observers following a list of predefined criteria and consensus was sought. Frequency distributions of the different categorical data were reported. RESULTS: Median duration of clinical signs at time of presentation was 14 days (range, 1‐90). Neurological examination was abnormal in 30/31 cats. On MRI, lesions affecting the CNS were diagnosed in 18/31 cats, lesions in both CNS and PNS in 12/31, and lesions in the PNS only in 1/31. Intracranial lesions were diagnosed in 22 cats (extra‐axial, 7/22; intra‐axial, 2/22; mixed, 13/22), and spinal lesions were diagnosed in 12 (6/12 involving the conus medullaris and lumbosacral plexuses). Infiltration of adjacent extra‐neural tissue was present in 11/31 cases. Contrast enhancement was seen in all lesions, being marked in 25/30. Meningeal enhancement was present in all but 2 cases. Several distinct MRI patterns were observed. CONCLUSIONS AND CLINICAL IMPORTANCE: Nervous system lymphoma in cats has a wide range of MRI features, of which none is pathognomonic. However, together with clinical data and cerebrospinal fluid (CSF) analysis, MRI may provide a strong tentative antemortem diagnosis.
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spelling pubmed-89652332022-04-05 Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats Durand, Alexane Keenihan, Erin Schweizer, Daniela Maiolini, Arianna Guevar, Julien Oevermann, Anna Gutierrez‐Quintana, Rodrigo J Vet Intern Med SMALL ANIMAL BACKGROUND: Lymphoma is the most common spinal cord neoplasm and second most common intracranial tumor in cats, but description of specific magnetic resonance imaging (MRI) features is lacking. OBJECTIVE: Describe the clinical and MRI features of lymphoma affecting the central (CNS) or peripheral (PNS) nervous system or both in cats. ANIMALS: Thirty‐one cats with confirmed cytological or histopathological diagnosis or both of lymphoma involving the CNS or PNS or both, and MRI findings of the lesions. METHODS: Multicenter retrospective descriptive study. Signalment and medical information were recorded. Magnetic resonance imaging findings were reviewed by 3 observers following a list of predefined criteria and consensus was sought. Frequency distributions of the different categorical data were reported. RESULTS: Median duration of clinical signs at time of presentation was 14 days (range, 1‐90). Neurological examination was abnormal in 30/31 cats. On MRI, lesions affecting the CNS were diagnosed in 18/31 cats, lesions in both CNS and PNS in 12/31, and lesions in the PNS only in 1/31. Intracranial lesions were diagnosed in 22 cats (extra‐axial, 7/22; intra‐axial, 2/22; mixed, 13/22), and spinal lesions were diagnosed in 12 (6/12 involving the conus medullaris and lumbosacral plexuses). Infiltration of adjacent extra‐neural tissue was present in 11/31 cases. Contrast enhancement was seen in all lesions, being marked in 25/30. Meningeal enhancement was present in all but 2 cases. Several distinct MRI patterns were observed. CONCLUSIONS AND CLINICAL IMPORTANCE: Nervous system lymphoma in cats has a wide range of MRI features, of which none is pathognomonic. However, together with clinical data and cerebrospinal fluid (CSF) analysis, MRI may provide a strong tentative antemortem diagnosis. John Wiley & Sons, Inc. 2022-01-20 2022-03 /pmc/articles/PMC8965233/ /pubmed/35048412 http://dx.doi.org/10.1111/jvim.16350 Text en © 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle SMALL ANIMAL
Durand, Alexane
Keenihan, Erin
Schweizer, Daniela
Maiolini, Arianna
Guevar, Julien
Oevermann, Anna
Gutierrez‐Quintana, Rodrigo
Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats
title Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats
title_full Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats
title_fullStr Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats
title_full_unstemmed Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats
title_short Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats
title_sort clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965233/
https://www.ncbi.nlm.nih.gov/pubmed/35048412
http://dx.doi.org/10.1111/jvim.16350
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