Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures

A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from β,γ-unsaturated ketoesters in low melting ʟ-(+)-tartaric acid–N,N-dimethylurea mixtures is reported. This solvent-free method is very general and provides easy access to 5-unsubstituted dihydropyrimidinone-4-carboxylate derivati...

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Autores principales: Gore, Sangram, Baskaran, Sundarababu, König, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2022
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965339/
https://www.ncbi.nlm.nih.gov/pubmed/35387381
http://dx.doi.org/10.3762/bjoc.18.37
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author Gore, Sangram
Baskaran, Sundarababu
König, Burkhard
author_facet Gore, Sangram
Baskaran, Sundarababu
König, Burkhard
author_sort Gore, Sangram
collection PubMed
description A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from β,γ-unsaturated ketoesters in low melting ʟ-(+)-tartaric acid–N,N-dimethylurea mixtures is reported. This solvent-free method is very general and provides easy access to 5-unsubstituted dihydropyrimidinone-4-carboxylate derivatives in good yields.
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spelling pubmed-89653392022-04-05 Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures Gore, Sangram Baskaran, Sundarababu König, Burkhard Beilstein J Org Chem Full Research Paper A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from β,γ-unsaturated ketoesters in low melting ʟ-(+)-tartaric acid–N,N-dimethylurea mixtures is reported. This solvent-free method is very general and provides easy access to 5-unsubstituted dihydropyrimidinone-4-carboxylate derivatives in good yields. Beilstein-Institut 2022-03-22 /pmc/articles/PMC8965339/ /pubmed/35387381 http://dx.doi.org/10.3762/bjoc.18.37 Text en Copyright © 2022, Gore et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Full Research Paper
Gore, Sangram
Baskaran, Sundarababu
König, Burkhard
Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures
title Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures
title_full Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures
title_fullStr Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures
title_full_unstemmed Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures
title_short Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures
title_sort synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965339/
https://www.ncbi.nlm.nih.gov/pubmed/35387381
http://dx.doi.org/10.3762/bjoc.18.37
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