Plaque-targeted, proteolysis-resistant, activatable and MRI-visible nano-GLP-1 receptor agonist targets smooth muscle cell differentiation in atherosclerosis

Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists are powerful glycemia-lowering agents, which have systematically been shown to lower cardiovascular events and mortality. These beneficial effects were difficult to pinpoint within atherosclerotic plaque due to lack of particular specifi...

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Detalles Bibliográficos
Autores principales: Maiseyeu, Andrei, Di, Lin, Ravodina, Anastasia, Barajas-Espinosa, Alma, Sakamoto, Atsushi, Chaplin, Alice, Zhong, Jixin, Gao, Huiyun, Mignery, Matthew, Narula, Navneet, Finn, Aloke V., Rajagopalan, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965488/
https://www.ncbi.nlm.nih.gov/pubmed/35401813
http://dx.doi.org/10.7150/thno.66456

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