Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche

The endoplasmic reticulum unfolded protein response (UPR) is a conserved adaptive signaling in ER homeostasis and has emerged as critical in highly proliferating cells and potential treatment target for acute T-cell lymphoblastic leukemia (T-ALL). Methods: in this study, we assessed the transcriptom...

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Detalles Bibliográficos
Autores principales: Liu, Cui, Chen, Qiuyun, Shang, Yinghui, Chen, Lechuang, Myers, Jay, Awadallah, Amad, Sun, Jinger, Yu, Shuiliang, Umphred-Wilson, Katharine, Che, Danian, Dou, Yingtong, Li, Luoyi, Wearsch, Pamela, Ramírez-Bergeron, Diana, Beck, Rose, Xin, Wei, Jin, Ge, Adoro, Stanley, Zhou, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965499/
https://www.ncbi.nlm.nih.gov/pubmed/35401837
http://dx.doi.org/10.7150/thno.67710

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