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High-Sensitivity Troponin: A Review on Characteristics, Assessment, and Clinical Implications

The use of high-sensitivity cardiac troponin (hs-cTn) assays has become part of the daily practice in most of the laboratories worldwide in the initial evaluation of the typical chest pain. Due to their early surge, the use of hs-cTn may reduce the time needed to recognise myocardial infarctions (MI...

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Autores principales: Lazar, Diana Raluca, Lazar, Florin-Leontin, Homorodean, Calin, Cainap, Calin, Focsan, Monica, Cainap, Simona, Olinic, Dan Mircea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965602/
https://www.ncbi.nlm.nih.gov/pubmed/35371340
http://dx.doi.org/10.1155/2022/9713326
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author Lazar, Diana Raluca
Lazar, Florin-Leontin
Homorodean, Calin
Cainap, Calin
Focsan, Monica
Cainap, Simona
Olinic, Dan Mircea
author_facet Lazar, Diana Raluca
Lazar, Florin-Leontin
Homorodean, Calin
Cainap, Calin
Focsan, Monica
Cainap, Simona
Olinic, Dan Mircea
author_sort Lazar, Diana Raluca
collection PubMed
description The use of high-sensitivity cardiac troponin (hs-cTn) assays has become part of the daily practice in most of the laboratories worldwide in the initial evaluation of the typical chest pain. Due to their early surge, the use of hs-cTn may reduce the time needed to recognise myocardial infarctions (MI), which is vital for the patients presenting in the emergency departments for chest pain. The latest European Society of Cardiology Guidelines did not only recognise their central role in the diagnosis algorithm but also recommended their use for rapid rule-in/rule-out of MI. High-sensitivity cardiac troponins are also powerful prognostic markers for long-term events and mortality, not only in a wide spectrum of other cardiovascular diseases (CVD) but also in several non-CVD pathologies. Moreover, these biomarkers became a powerful tool in special populations, such as paediatric patients and, most recently, COVID-19 patients. Although highly investigated, the assessment and interpretation of the hs-cTn changes are still challenging in the patients with basal elevation such as CKD or critically ill patients. Moreover, there are still various analytical characteristics not completely understood, such as circadian or sex variability, with major clinical implications. In this context, the present review focuses on summarizing the most recent research in the current use of hs-cTn, with a main consideration for its role in the diagnosis of MI but also its prognostic value. We have also carefully selected the most important studies regarding the challenges faced by clinicians from different specialties in the correct interpretation of this biomarker. Moreover, future perspectives have been proposed and analysed, as more research and cross-disciplinary collaboration are necessary to improve their performance.
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spelling pubmed-89656022022-03-31 High-Sensitivity Troponin: A Review on Characteristics, Assessment, and Clinical Implications Lazar, Diana Raluca Lazar, Florin-Leontin Homorodean, Calin Cainap, Calin Focsan, Monica Cainap, Simona Olinic, Dan Mircea Dis Markers Review Article The use of high-sensitivity cardiac troponin (hs-cTn) assays has become part of the daily practice in most of the laboratories worldwide in the initial evaluation of the typical chest pain. Due to their early surge, the use of hs-cTn may reduce the time needed to recognise myocardial infarctions (MI), which is vital for the patients presenting in the emergency departments for chest pain. The latest European Society of Cardiology Guidelines did not only recognise their central role in the diagnosis algorithm but also recommended their use for rapid rule-in/rule-out of MI. High-sensitivity cardiac troponins are also powerful prognostic markers for long-term events and mortality, not only in a wide spectrum of other cardiovascular diseases (CVD) but also in several non-CVD pathologies. Moreover, these biomarkers became a powerful tool in special populations, such as paediatric patients and, most recently, COVID-19 patients. Although highly investigated, the assessment and interpretation of the hs-cTn changes are still challenging in the patients with basal elevation such as CKD or critically ill patients. Moreover, there are still various analytical characteristics not completely understood, such as circadian or sex variability, with major clinical implications. In this context, the present review focuses on summarizing the most recent research in the current use of hs-cTn, with a main consideration for its role in the diagnosis of MI but also its prognostic value. We have also carefully selected the most important studies regarding the challenges faced by clinicians from different specialties in the correct interpretation of this biomarker. Moreover, future perspectives have been proposed and analysed, as more research and cross-disciplinary collaboration are necessary to improve their performance. Hindawi 2022-03-28 /pmc/articles/PMC8965602/ /pubmed/35371340 http://dx.doi.org/10.1155/2022/9713326 Text en Copyright © 2022 Diana Raluca Lazar et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lazar, Diana Raluca
Lazar, Florin-Leontin
Homorodean, Calin
Cainap, Calin
Focsan, Monica
Cainap, Simona
Olinic, Dan Mircea
High-Sensitivity Troponin: A Review on Characteristics, Assessment, and Clinical Implications
title High-Sensitivity Troponin: A Review on Characteristics, Assessment, and Clinical Implications
title_full High-Sensitivity Troponin: A Review on Characteristics, Assessment, and Clinical Implications
title_fullStr High-Sensitivity Troponin: A Review on Characteristics, Assessment, and Clinical Implications
title_full_unstemmed High-Sensitivity Troponin: A Review on Characteristics, Assessment, and Clinical Implications
title_short High-Sensitivity Troponin: A Review on Characteristics, Assessment, and Clinical Implications
title_sort high-sensitivity troponin: a review on characteristics, assessment, and clinical implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965602/
https://www.ncbi.nlm.nih.gov/pubmed/35371340
http://dx.doi.org/10.1155/2022/9713326
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