Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes

Type 1 diabetes is characterized by a loss of tolerance to pancreatic β-cell autoantigens and defects in regulatory T-cell (Treg) function. In preclinical models, immunotherapy with MHC-selective, autoantigenic peptides restores immune tolerance, prevents diabetes, and shows greater potency when mul...

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Detalles Bibliográficos
Autores principales: Liu, Yuk-Fun, Powrie, Jake, Arif, Sefina, Yang, Jennie H.M., Williams, Evangelia, Khatri, Leena, Joshi, Mamta, Lhuillier, Loic, Fountoulakis, Nikolaos, Smith, Emma, Beam, Craig, Lorenc, Anna, Peakman, Mark, Tree, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2022
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965665/
https://www.ncbi.nlm.nih.gov/pubmed/35073398
http://dx.doi.org/10.2337/db21-0728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965665/
https://www.ncbi.nlm.nih.gov/pubmed/35073398
http://dx.doi.org/10.2337/db21-0728

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