Cargando…

Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes

Type 1 diabetes is characterized by a loss of tolerance to pancreatic β-cell autoantigens and defects in regulatory T-cell (Treg) function. In preclinical models, immunotherapy with MHC-selective, autoantigenic peptides restores immune tolerance, prevents diabetes, and shows greater potency when mul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yuk-Fun, Powrie, Jake, Arif, Sefina, Yang, Jennie H.M., Williams, Evangelia, Khatri, Leena, Joshi, Mamta, Lhuillier, Loic, Fountoulakis, Nikolaos, Smith, Emma, Beam, Craig, Lorenc, Anna, Peakman, Mark, Tree, Timothy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2022
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965665/ https://www.ncbi.nlm.nih.gov/pubmed/35073398 http://dx.doi.org/10.2337/db21-0728

Ejemplares similares

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death
por: Arif, Sefina, et al.
Publicado: (2011)

Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes
por: Arif, Sefina, et al.
Publicado: (2014)

Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects
por: Arif, Sefina, et al.
Publicado: (2021)

GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells
por: Arif, Sefina, et al.
Publicado: (2020)

Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline
por: Orban, Tihamer, et al.
Publicado: (2014)

Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials
por: Arif, Sefina, et al.
Publicado: (2023)

Evaluating T cell responses prior to the onset of type 1 diabetes
por: Arif, Sefina, et al.
Publicado: (2022)

Circulating Preproinsulin Signal Peptide–Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells
por: Kronenberg, Deborah, et al.
Publicado: (2012)

Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture
por: Allen, Jennifer S., et al.
Publicado: (2009)

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression
por: Tree, Timothy I.M., et al.
Publicado: (2010)

Reciprocating living kidney donor generosity: tax credits, health insurance and an outcomes registry
por: Joshi, Shivam, et al.
Publicado: (2016)

Allodepleted T‐cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft‐versus‐host disease (GVHD) in the absence of GVHD prophylaxis
por: Roy, Denis Claude, et al.
Publicado: (2019)

First UK case report of kidney transplantation from an HIV-infected deceased donor to two HIV-infected recipients
por: Nolan, Eileen, et al.
Publicado: (2018)

Uterus Transplantation as a Therapy Method in Mayer-Rokitansky-Küster-Hauser Syndrome
por: Georgopapadakos, Nikolaos, et al.
Publicado: (2019)

Impact of CMV reactivation on relapse of acute myeloid leukemia after HCT is dependent on disease stage and ATG
por: Turki, Amin T., et al.
Publicado: (2021)

Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity
por: Knight, Robin R., et al.
Publicado: (2013)

Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835–3845
por: Arif, Sefina, et al.
Publicado: (2015)

Improved GRFS after posttransplant cyclophosphamide-based vs ATG-based HLA-mismatched unrelated donor transplant
por: Jimenez Jimenez, Antonio, et al.
Publicado: (2022)

Activation status dictates the function of unlicensed natural killer cells in mice and humans
por: Aguilar, Ethan G., et al.
Publicado: (2021)

Incidence, clinical presentation, risk factors, outcomes, and biomarkers in de novo late acute GVHD
por: Akahoshi, Yu, et al.
Publicado: (2023)

Simultaneous Detection of Circulating Autoreactive CD8(+) T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers
por: Velthuis, Jurjen H., et al.
Publicado: (2010)

The Simplified Comorbidity Index: a new tool for prediction of nonrelapse mortality in allo-HCT
por: Shouval, Roni, et al.
Publicado: (2022)

Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease
por: Verhagen, Johan, et al.
Publicado: (2019)

Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells: Implications for the Timing of Tolerizing Immunotherapy
por: Bertin-Maghit, Sebastien, et al.
Publicado: (2011)

Capture and enrichment of CD34-positive haematopoietic stem and progenitor cells from blood circulation using P-selectin in an implantable device
por: Wojciechowski, Joel C, et al.
Publicado: (2008)

Conversion to sirolimus for chronic renal allograft dysfunction: risk factors for graft loss and severe side effects
por: Abramowicz, Daniel, et al.
Publicado: (2008)

Risk factors for polyoma virus nephropathy
por: Prince, Olivier, et al.
Publicado: (2009)

Benefit of kidney transplantation beyond 70 years of age
por: Heldal, Kristian, et al.
Publicado: (2010)

Pancreas transplantation: differences in activity between Europe and the United States
por: Manuel González-Posada, José, et al.
Publicado: (2009)

Improvement in kidney transplantation in the Balkans after the Istanbul Declaration: where do we stand today?
por: Spasovski, Goce, et al.
Publicado: (2016)

A comparative study of reduced dose alemtuzumab in matched unrelated donor and related donor reduced intensity transplants
por: Jardine, Laura, et al.
Publicado: (2015)

Chronic Renal Transplant Rejection and Possible Anti-Proliferative Drug Targets
por: Bhatti, Adnan Bashir, et al.
Publicado: (2015)

Establishment and operation of a Good Manufacturing Practice-compliant allogeneic Epstein-Barr virus (EBV)-specific cytotoxic cell bank for the treatment of EBV-associated lymphoproliferative disease
por: Vickers, Mark A, et al.
Publicado: (2014)

BK polyoma virus infection and renal disease in non-renal solid organ transplantation
por: Kuppachi, Sarat, et al.
Publicado: (2016)

Therapeutic drug monitoring of enteric-coated mycophenolate sodium by limited sampling strategies is associated with a high rate of failure
por: Hougardy, Jean-Michel, et al.
Publicado: (2016)

Improved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning
por: Townsend, William M, et al.
Publicado: (2013)

Identification of a Patient Population Previously Not Considered for Organ Donation
por: Barrois, Brad
Publicado: (2016)

Liver Transplantation after Exertional Heatstroke-Induced Acute Liver Failure
por: Inayat, Faisal, et al.
Publicado: (2016)

An Unusual Presentation of Nocardiosis in an Allogeneic Transplant Recipient
por: Ibrahim, Uroosa, et al.
Publicado: (2016)

Outcomes of living kidney donors with medullary sponge kidney
por: Cheungpasitporn, Wisit, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_22kcg7vtvvf0mrmokmn53p3ivd