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Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells

Studies of monogenic diabetes are particularly useful because we can gain insight into the molecular events of pancreatic β-cell failure. Maturity-onset diabetes of the young 1 (MODY1) is a form of monogenic diabetes caused by a mutation in the HNF4A gene. Human-induced pluripotent stem cells (hiPSC...

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Detalles Bibliográficos
Autores principales:	Carrasco, Manuel, Wang, Chencheng, Søviknes, Anne M., Bjørlykke, Yngvild, Abadpour, Shadab, Paulo, Joao A., Tjora, Erling, Njølstad, Pål, Ghabayen, Jonas, Nermoen, Ingrid, Lyssenko, Valeriya, Chera, Simona, Ghila, Luiza M., Vaudel, Marc, Scholz, Hanne, Ræder, Helge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2022
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965667/ https://www.ncbi.nlm.nih.gov/pubmed/35043148 http://dx.doi.org/10.2337/db20-1279

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