Cargando…
Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures
Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
KeAi Publishing
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965695/ https://www.ncbi.nlm.nih.gov/pubmed/35386316 http://dx.doi.org/10.1016/j.bioactmat.2022.01.027 |
| _version_ | 1784678489523224576 |
|---|---|
| author | Gonçalves da Costa Sousa, Mauricio Conceição de Almeida, Gabriela Martins Mota, Danilo César Andrade da Costa, Rosiane Dias, Simoni Campos Limberger, Samuel Nunes Ko, Frank Lin, Li Ting Haney, Evan F. Etayash, Hashem Baquir, Beverlie Trimble, Michael J. Shen, Ya Su, Zheng Haapasalo, Markus Pletzer, Daniel Chaves de Souza, Letícia Schuindt Teixeira, Gláucia Silva, Renato M. Hancock, Robert E.W. Franco, Octavio Luiz Berto Rezende, Taia Maria |
| author_facet | Gonçalves da Costa Sousa, Mauricio Conceição de Almeida, Gabriela Martins Mota, Danilo César Andrade da Costa, Rosiane Dias, Simoni Campos Limberger, Samuel Nunes Ko, Frank Lin, Li Ting Haney, Evan F. Etayash, Hashem Baquir, Beverlie Trimble, Michael J. Shen, Ya Su, Zheng Haapasalo, Markus Pletzer, Daniel Chaves de Souza, Letícia Schuindt Teixeira, Gláucia Silva, Renato M. Hancock, Robert E.W. Franco, Octavio Luiz Berto Rezende, Taia Maria |
| author_sort | Gonçalves da Costa Sousa, Mauricio |
| collection | PubMed |
| description | Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen hydrogels and poly(vinyl alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002 (each at 50 mg/g). Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against Enterococcus faecalis, Staphylococcus aureus and a multispecies oral biofilm, besides anti-inflammatory activities. The in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation, when compared to empty teeth fragments. Thus, we designed a strong antimicrobial, immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures. |
| format | Online Article Text |
| id | pubmed-8965695 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | KeAi Publishing |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-89656952022-04-05 Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures Gonçalves da Costa Sousa, Mauricio Conceição de Almeida, Gabriela Martins Mota, Danilo César Andrade da Costa, Rosiane Dias, Simoni Campos Limberger, Samuel Nunes Ko, Frank Lin, Li Ting Haney, Evan F. Etayash, Hashem Baquir, Beverlie Trimble, Michael J. Shen, Ya Su, Zheng Haapasalo, Markus Pletzer, Daniel Chaves de Souza, Letícia Schuindt Teixeira, Gláucia Silva, Renato M. Hancock, Robert E.W. Franco, Octavio Luiz Berto Rezende, Taia Maria Bioact Mater Article Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen hydrogels and poly(vinyl alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002 (each at 50 mg/g). Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against Enterococcus faecalis, Staphylococcus aureus and a multispecies oral biofilm, besides anti-inflammatory activities. The in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation, when compared to empty teeth fragments. Thus, we designed a strong antimicrobial, immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures. KeAi Publishing 2022-02-01 /pmc/articles/PMC8965695/ /pubmed/35386316 http://dx.doi.org/10.1016/j.bioactmat.2022.01.027 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Article Gonçalves da Costa Sousa, Mauricio Conceição de Almeida, Gabriela Martins Mota, Danilo César Andrade da Costa, Rosiane Dias, Simoni Campos Limberger, Samuel Nunes Ko, Frank Lin, Li Ting Haney, Evan F. Etayash, Hashem Baquir, Beverlie Trimble, Michael J. Shen, Ya Su, Zheng Haapasalo, Markus Pletzer, Daniel Chaves de Souza, Letícia Schuindt Teixeira, Gláucia Silva, Renato M. Hancock, Robert E.W. Franco, Octavio Luiz Berto Rezende, Taia Maria Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures |
| title | Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures |
| title_full | Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures |
| title_fullStr | Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures |
| title_full_unstemmed | Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures |
| title_short | Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures |
| title_sort | antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965695/ https://www.ncbi.nlm.nih.gov/pubmed/35386316 http://dx.doi.org/10.1016/j.bioactmat.2022.01.027 |
| work_keys_str_mv | AT goncalvesdacostasousamauricio antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT conceicaodealmeidagabriela antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT martinsmotadanilocesar antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT andradedacostarosiane antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT diassimonicampos antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT limbergersamuelnunes antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT kofrank antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT linliting antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT haneyevanf antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT etayashhashem antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT baquirbeverlie antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT trimblemichaelj antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT shenya antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT suzheng antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT haapasalomarkus antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT pletzerdaniel antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT chavesdesouzaleticia antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT schuindtteixeiraglaucia antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT silvarenatom antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT hancockrobertew antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT francooctavioluiz antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures AT bertorezendetaiamaria antibiofilmandimmunomodulatoryresorbablenanofibrousfilingfordentalpulpregenerativeprocedures |