m(6)A-induced repression of SIAH1 facilitates alternative splicing of androgen receptor variant 7 by regulating CPSF1

Androgen receptor splice variant 7 (AR-v7), a constitutively active transcription factor, plays a crucial role in the progression of castration-resistant prostate cancer (CRPC). Here, we found that the cleavage and polyadenylation specificity factor 1 (CPSF1) (the largest subunit of the multi-protei...

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Detalles Bibliográficos
Autores principales: Xia, Lei, Han, Qing, Duan, Xuehui, Zhu, Yinjie, Pan, Jiahua, Dong, Baijun, Xia, Weiliang, Xue, Wei, Sha, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965770/
https://www.ncbi.nlm.nih.gov/pubmed/35402071
http://dx.doi.org/10.1016/j.omtn.2022.03.008

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