Demography, patterns of care, and survival outcomes in patients with salivary duct carcinoma: an individual patient data analysis of 857 patients

AIM: Salivary duct carcinoma (SDC) is a rare and aggressive malignancy. The optimal treatment protocols are debated. METHODOLOGY: A systematic search and individual patient data analysis of published cases of SDC was performed. SPSS v21 was used for statistical analysis. RESULTS: Data of 857 patient...

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Detalles Bibliográficos
Autores principales: Giridhar, Prashanth, Venkatesulu, Bhanu Prasad, Yoo, Ryan, V, Pragathee, Rath, Goura K, Mallick, Supriya, Upadhyay, Ashishdutt, Chan, Dennis Pai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965816/
https://www.ncbi.nlm.nih.gov/pubmed/35369277
http://dx.doi.org/10.2144/fsoa-2021-0052
Descripción
Sumario:AIM: Salivary duct carcinoma (SDC) is a rare and aggressive malignancy. The optimal treatment protocols are debated. METHODOLOGY: A systematic search and individual patient data analysis of published cases of SDC was performed. SPSS v21 was used for statistical analysis. RESULTS: Data of 857 patients available. Median overall survival (OS) and progression-free survival (PFS) of the entire cohort 42 months and 24 months. Nodal involvement, males, primary size >5 cm, androgen receptor (AR) negativity significantly worse OS. Patients with surgery had a favorable median PFS (p = 0.000) and OS (p = 0.077). Patients with adjuvant radiation had better PFS (30 vs 18 months; p = 0.077). CONCLUSION: SDC has modest survival. Surgery and adjuvant radiation should be advocated for all patients. AR expression appears prognostic for survival.

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