MiR-223 as a Regulator and Therapeutic Target in Liver Diseases

MicroRNAs (miRNAs) are endogenous non-coding single-stranded small molecule RNAs consisting of 20–24 nucleotides that are highly conserved in species evolution. Expression of miRNAs is strictly tissue-specific, and it is chronological in fungi and plants, as well as in animals. MiR-223 has been show...

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Autores principales: Gu, Jiarong, Xu, Hao, Chen, Yandong, Li, Na, Hou, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965842/
https://www.ncbi.nlm.nih.gov/pubmed/35371024
http://dx.doi.org/10.3389/fimmu.2022.860661
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author Gu, Jiarong
Xu, Hao
Chen, Yandong
Li, Na
Hou, Xin
author_facet Gu, Jiarong
Xu, Hao
Chen, Yandong
Li, Na
Hou, Xin
author_sort Gu, Jiarong
collection PubMed
description MicroRNAs (miRNAs) are endogenous non-coding single-stranded small molecule RNAs consisting of 20–24 nucleotides that are highly conserved in species evolution. Expression of miRNAs is strictly tissue-specific, and it is chronological in fungi and plants, as well as in animals. MiR-223 has been shown to play a key role in innate immunity, and dysregulation of its expression contributes to the pathogenesis of multiple inflammatory diseases, and cancers. In this article the biosynthesis and functions of miR-223 in innate immunity are reviewed, and the role of miR-223 in liver physiopathology and therapeutic prospects are highlighted.
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spelling pubmed-89658422022-03-31 MiR-223 as a Regulator and Therapeutic Target in Liver Diseases Gu, Jiarong Xu, Hao Chen, Yandong Li, Na Hou, Xin Front Immunol Immunology MicroRNAs (miRNAs) are endogenous non-coding single-stranded small molecule RNAs consisting of 20–24 nucleotides that are highly conserved in species evolution. Expression of miRNAs is strictly tissue-specific, and it is chronological in fungi and plants, as well as in animals. MiR-223 has been shown to play a key role in innate immunity, and dysregulation of its expression contributes to the pathogenesis of multiple inflammatory diseases, and cancers. In this article the biosynthesis and functions of miR-223 in innate immunity are reviewed, and the role of miR-223 in liver physiopathology and therapeutic prospects are highlighted. Frontiers Media S.A. 2022-03-16 /pmc/articles/PMC8965842/ /pubmed/35371024 http://dx.doi.org/10.3389/fimmu.2022.860661 Text en Copyright © 2022 Gu, Xu, Chen, Li and Hou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Gu, Jiarong
Xu, Hao
Chen, Yandong
Li, Na
Hou, Xin
MiR-223 as a Regulator and Therapeutic Target in Liver Diseases
title MiR-223 as a Regulator and Therapeutic Target in Liver Diseases
title_full MiR-223 as a Regulator and Therapeutic Target in Liver Diseases
title_fullStr MiR-223 as a Regulator and Therapeutic Target in Liver Diseases
title_full_unstemmed MiR-223 as a Regulator and Therapeutic Target in Liver Diseases
title_short MiR-223 as a Regulator and Therapeutic Target in Liver Diseases
title_sort mir-223 as a regulator and therapeutic target in liver diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965842/
https://www.ncbi.nlm.nih.gov/pubmed/35371024
http://dx.doi.org/10.3389/fimmu.2022.860661
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