Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility

Glucose-responsive insulin represents a promising approach to regulate blood glucose levels. We previously showed that attaching two fluorophenylboronic acid (FPBA) residues to the C-terminal B chain of insulin glargine led to glucose-dependent solubility. Herein, we demonstrated that relocating FPB...

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Autores principales: Lin, Nai-Pin, Zheng, Nan, Purushottam, Landa, Zhang, Yi Wolf, Chou, Danny Hung-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965884/
https://www.ncbi.nlm.nih.gov/pubmed/35372263
http://dx.doi.org/10.3389/fchem.2022.859133
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author Lin, Nai-Pin
Zheng, Nan
Purushottam, Landa
Zhang, Yi Wolf
Chou, Danny Hung-Chieh
author_facet Lin, Nai-Pin
Zheng, Nan
Purushottam, Landa
Zhang, Yi Wolf
Chou, Danny Hung-Chieh
author_sort Lin, Nai-Pin
collection PubMed
description Glucose-responsive insulin represents a promising approach to regulate blood glucose levels. We previously showed that attaching two fluorophenylboronic acid (FPBA) residues to the C-terminal B chain of insulin glargine led to glucose-dependent solubility. Herein, we demonstrated that relocating FPBA from B chain to A chain increased the baseline solubility without affecting its potency. Furthermore, increasing the number of FPBA groups led to increased glucose-dependent solubility.
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spelling pubmed-89658842022-03-31 Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility Lin, Nai-Pin Zheng, Nan Purushottam, Landa Zhang, Yi Wolf Chou, Danny Hung-Chieh Front Chem Chemistry Glucose-responsive insulin represents a promising approach to regulate blood glucose levels. We previously showed that attaching two fluorophenylboronic acid (FPBA) residues to the C-terminal B chain of insulin glargine led to glucose-dependent solubility. Herein, we demonstrated that relocating FPBA from B chain to A chain increased the baseline solubility without affecting its potency. Furthermore, increasing the number of FPBA groups led to increased glucose-dependent solubility. Frontiers Media S.A. 2022-03-16 /pmc/articles/PMC8965884/ /pubmed/35372263 http://dx.doi.org/10.3389/fchem.2022.859133 Text en Copyright © 2022 Lin, Zheng, Purushottam, Zhang and Chou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Lin, Nai-Pin
Zheng, Nan
Purushottam, Landa
Zhang, Yi Wolf
Chou, Danny Hung-Chieh
Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility
title Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility
title_full Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility
title_fullStr Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility
title_full_unstemmed Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility
title_short Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility
title_sort synthesis and characterization of phenylboronic acid-modified insulin with glucose-dependent solubility
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965884/
https://www.ncbi.nlm.nih.gov/pubmed/35372263
http://dx.doi.org/10.3389/fchem.2022.859133
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