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Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation
Laser powder bed fusion (L-PBF) of magnesium (Mg) alloy porous scaffolds is expected to solve the dual challenges from customized structures and biodegradable functions required for repairing bone defects. However, one of the key technical difficulties lies in the poor L-PBF process performance of M...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965912/ https://www.ncbi.nlm.nih.gov/pubmed/35415288 http://dx.doi.org/10.1016/j.bioactmat.2022.02.020 |
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author | Liu, Jinge Liu, Bingchun Min, Shuyuan Yin, Bangzhao Peng, Bo Yu, Zishi Wang, Caimei Ma, Xiaolin Wen, Peng Tian, Yun Zheng, Yufeng |
author_facet | Liu, Jinge Liu, Bingchun Min, Shuyuan Yin, Bangzhao Peng, Bo Yu, Zishi Wang, Caimei Ma, Xiaolin Wen, Peng Tian, Yun Zheng, Yufeng |
author_sort | Liu, Jinge |
collection | PubMed |
description | Laser powder bed fusion (L-PBF) of magnesium (Mg) alloy porous scaffolds is expected to solve the dual challenges from customized structures and biodegradable functions required for repairing bone defects. However, one of the key technical difficulties lies in the poor L-PBF process performance of Mg, contributed by the high susceptibility to oxidation, vaporization, thermal expansion, and powder attachment etc. This work investigated the influence of L-PBF energy input and scanning strategy on the formation quality of porous scaffolds by using WE43 powder, and characterized the microstructure, mechanical properties, biocompatibility, biodegradation and osteogenic effect of the as-built WE43 porous scaffolds. With the customized energy input and scanning strategy, the relative density of struts reached over 99.5%, and the geometrical error between the designed and the fabricated porosity declined to below 10%. Massive secondary phases including intermetallic precipitates and oxides were observed. The compressive strength (4.37–23.49 MPa) and elastic modulus (154.40–873.02 MPa) were comparable to those of cancellous bone. Good biocompatibility was observed by in vitro cell viability and in vivo implantation. The biodegradation of as-built porous scaffolds promoted the osteogenic effect, but the structural integrity devastated after 12 h by the immersion tests in Hank's solution and after 4 weeks by the implantation in rabbits' femur, indicating an excessively rapid degradation rate. |
format | Online Article Text |
id | pubmed-8965912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-89659122022-04-11 Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation Liu, Jinge Liu, Bingchun Min, Shuyuan Yin, Bangzhao Peng, Bo Yu, Zishi Wang, Caimei Ma, Xiaolin Wen, Peng Tian, Yun Zheng, Yufeng Bioact Mater Article Laser powder bed fusion (L-PBF) of magnesium (Mg) alloy porous scaffolds is expected to solve the dual challenges from customized structures and biodegradable functions required for repairing bone defects. However, one of the key technical difficulties lies in the poor L-PBF process performance of Mg, contributed by the high susceptibility to oxidation, vaporization, thermal expansion, and powder attachment etc. This work investigated the influence of L-PBF energy input and scanning strategy on the formation quality of porous scaffolds by using WE43 powder, and characterized the microstructure, mechanical properties, biocompatibility, biodegradation and osteogenic effect of the as-built WE43 porous scaffolds. With the customized energy input and scanning strategy, the relative density of struts reached over 99.5%, and the geometrical error between the designed and the fabricated porosity declined to below 10%. Massive secondary phases including intermetallic precipitates and oxides were observed. The compressive strength (4.37–23.49 MPa) and elastic modulus (154.40–873.02 MPa) were comparable to those of cancellous bone. Good biocompatibility was observed by in vitro cell viability and in vivo implantation. The biodegradation of as-built porous scaffolds promoted the osteogenic effect, but the structural integrity devastated after 12 h by the immersion tests in Hank's solution and after 4 weeks by the implantation in rabbits' femur, indicating an excessively rapid degradation rate. KeAi Publishing 2022-02-24 /pmc/articles/PMC8965912/ /pubmed/35415288 http://dx.doi.org/10.1016/j.bioactmat.2022.02.020 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Jinge Liu, Bingchun Min, Shuyuan Yin, Bangzhao Peng, Bo Yu, Zishi Wang, Caimei Ma, Xiaolin Wen, Peng Tian, Yun Zheng, Yufeng Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation |
title | Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation |
title_full | Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation |
title_fullStr | Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation |
title_full_unstemmed | Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation |
title_short | Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation |
title_sort | biodegradable magnesium alloy we43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: process optimization, in vitro and in vivo investigation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965912/ https://www.ncbi.nlm.nih.gov/pubmed/35415288 http://dx.doi.org/10.1016/j.bioactmat.2022.02.020 |
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