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A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis

Immunoglobulin A (IgA) vasculitis (IgAV), also known as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. It is characterized by cutaneous hemorrhage, resulting from red blood cell leakage into the skin or mucosae, possibly caused by damage to small blood vessels. These acut...

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Autores principales: Xu, Shanshan, Han, Shanshan, Dai, Yanlin, Wang, Long, Zhang, Xia, Ding, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966136/
https://www.ncbi.nlm.nih.gov/pubmed/35370802
http://dx.doi.org/10.3389/fphys.2022.833954
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author Xu, Shanshan
Han, Shanshan
Dai, Yanlin
Wang, Long
Zhang, Xia
Ding, Ying
author_facet Xu, Shanshan
Han, Shanshan
Dai, Yanlin
Wang, Long
Zhang, Xia
Ding, Ying
author_sort Xu, Shanshan
collection PubMed
description Immunoglobulin A (IgA) vasculitis (IgAV), also known as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. It is characterized by cutaneous hemorrhage, resulting from red blood cell leakage into the skin or mucosae, possibly caused by damage to small blood vessels. These acute symptoms usually disappear without treatment. Endothelial cells are distributed on the inner surfaces of blood vessels and lymphatic vessels, and have important functions in metabolism and endocrine function, as well as being the primary targets of external stimuli and endogenous immune activity. Injury to endothelial cells is a feature of IgA vasculitis. Endothelial cell damage may be related to the deposition of immune complexes, the activation of complement, inflammatory factors, and chemokines, oxidative stress, hemodynamics, and coagulation factors. Both epigenetic mechanisms and genetic diversity provide a genetic background for endothelial cell injury. Here, research on the role of endothelial cells in allergic IgA vasculitis is reviewed.
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spelling pubmed-89661362022-03-31 A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis Xu, Shanshan Han, Shanshan Dai, Yanlin Wang, Long Zhang, Xia Ding, Ying Front Physiol Physiology Immunoglobulin A (IgA) vasculitis (IgAV), also known as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. It is characterized by cutaneous hemorrhage, resulting from red blood cell leakage into the skin or mucosae, possibly caused by damage to small blood vessels. These acute symptoms usually disappear without treatment. Endothelial cells are distributed on the inner surfaces of blood vessels and lymphatic vessels, and have important functions in metabolism and endocrine function, as well as being the primary targets of external stimuli and endogenous immune activity. Injury to endothelial cells is a feature of IgA vasculitis. Endothelial cell damage may be related to the deposition of immune complexes, the activation of complement, inflammatory factors, and chemokines, oxidative stress, hemodynamics, and coagulation factors. Both epigenetic mechanisms and genetic diversity provide a genetic background for endothelial cell injury. Here, research on the role of endothelial cells in allergic IgA vasculitis is reviewed. Frontiers Media S.A. 2022-03-16 /pmc/articles/PMC8966136/ /pubmed/35370802 http://dx.doi.org/10.3389/fphys.2022.833954 Text en Copyright © 2022 Xu, Han, Dai, Wang, Zhang and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Xu, Shanshan
Han, Shanshan
Dai, Yanlin
Wang, Long
Zhang, Xia
Ding, Ying
A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis
title A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis
title_full A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis
title_fullStr A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis
title_full_unstemmed A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis
title_short A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis
title_sort review of the mechanism of vascular endothelial injury in immunoglobulin a vasculitis
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966136/
https://www.ncbi.nlm.nih.gov/pubmed/35370802
http://dx.doi.org/10.3389/fphys.2022.833954
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