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Synthesis and cellular evaluation of click-chemistry probes to study the biological effects of alpha, beta-unsaturated carbonyls

Humans are commonly exposed to α,β-unsaturated carbonyls as both environmental toxins (e.g. acrolein) and therapeutic drugs (e.g. dimethylfumarate, DMFU, a front-line drug for the treatment of multiple sclerosis and psoriasis). These compounds undergo rapid Michael addition reactions with amine, imi...

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Detalles Bibliográficos
Autores principales:	Morozzi, Chiara, Sauerland, Max, Gamon, Luke F., Manandhar, Asmita, Ulven, Trond, Davies, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966197/ https://www.ncbi.nlm.nih.gov/pubmed/35358849 http://dx.doi.org/10.1016/j.redox.2022.102299

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