A PBPK Model of Ternary Cyclodextrin Complex of ST-246 Was Built to Achieve a Reasonable IV Infusion Regimen for the Treatment of Human Severe Smallpox

ST-246 is an oral drug against pathogenic orthopoxvirus infections. An intravenous formulation is required for some critical patients. A ternary complex of ST-246/meglumine/hydroxypropyl-β-cyclodextrin with well-improved solubility was successfully developed in our institute. The aim of this study w...

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Detalles Bibliográficos
Autores principales: Zhang, Zhiwei, Fu, Shuang, Wang, Furun, Yang, Chunmiao, Wang, Lingchao, Yang, Meiyan, Zhang, Wenpeng, Zhong, Wu, Zhuang, Xiaomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966223/
https://www.ncbi.nlm.nih.gov/pubmed/35370741
http://dx.doi.org/10.3389/fphar.2022.836356

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