The Construction of Cucurbit[7]uril-Based Supramolecular Nanomedicine for Glioma Therapy

Two supramolecular nanomedicines (CB[7]⊃DOX and CB[7]⊃CPT) based on the host–guest recognition between CB[7] and anticancer drugs were constructed. After supramolecular modification, the stability and water solubility of DOX and CPT were greatly improved, and the anticancer activities of chemotherap...

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Detalles Bibliográficos
Autores principales: Chen, Mantao, Hu, Chi, Zhang, Shengxiang, Wu, Dan, Mao, Zhengwei, Zheng, Xiujue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966231/
https://www.ncbi.nlm.nih.gov/pubmed/35372259
http://dx.doi.org/10.3389/fchem.2022.867815
Descripción
Sumario:Two supramolecular nanomedicines (CB[7]⊃DOX and CB[7]⊃CPT) based on the host–guest recognition between CB[7] and anticancer drugs were constructed. After supramolecular modification, the stability and water solubility of DOX and CPT were greatly improved, and the anticancer activities of chemotherapeutic drugs were effectively maintained. This work provided a simple but efficient method to enrich supramolecular nanomedicines for cancer therapy.

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