The Construction of Cucurbit[7]uril-Based Supramolecular Nanomedicine for Glioma Therapy

Two supramolecular nanomedicines (CB[7]⊃DOX and CB[7]⊃CPT) based on the host–guest recognition between CB[7] and anticancer drugs were constructed. After supramolecular modification, the stability and water solubility of DOX and CPT were greatly improved, and the anticancer activities of chemotherap...

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Autores principales: Chen, Mantao, Hu, Chi, Zhang, Shengxiang, Wu, Dan, Mao, Zhengwei, Zheng, Xiujue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966231/
https://www.ncbi.nlm.nih.gov/pubmed/35372259
http://dx.doi.org/10.3389/fchem.2022.867815
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author Chen, Mantao
Hu, Chi
Zhang, Shengxiang
Wu, Dan
Mao, Zhengwei
Zheng, Xiujue
author_facet Chen, Mantao
Hu, Chi
Zhang, Shengxiang
Wu, Dan
Mao, Zhengwei
Zheng, Xiujue
author_sort Chen, Mantao
collection PubMed
description Two supramolecular nanomedicines (CB[7]⊃DOX and CB[7]⊃CPT) based on the host–guest recognition between CB[7] and anticancer drugs were constructed. After supramolecular modification, the stability and water solubility of DOX and CPT were greatly improved, and the anticancer activities of chemotherapeutic drugs were effectively maintained. This work provided a simple but efficient method to enrich supramolecular nanomedicines for cancer therapy.
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spelling pubmed-89662312022-03-31 The Construction of Cucurbit[7]uril-Based Supramolecular Nanomedicine for Glioma Therapy Chen, Mantao Hu, Chi Zhang, Shengxiang Wu, Dan Mao, Zhengwei Zheng, Xiujue Front Chem Chemistry Two supramolecular nanomedicines (CB[7]⊃DOX and CB[7]⊃CPT) based on the host–guest recognition between CB[7] and anticancer drugs were constructed. After supramolecular modification, the stability and water solubility of DOX and CPT were greatly improved, and the anticancer activities of chemotherapeutic drugs were effectively maintained. This work provided a simple but efficient method to enrich supramolecular nanomedicines for cancer therapy. Frontiers Media S.A. 2022-03-16 /pmc/articles/PMC8966231/ /pubmed/35372259 http://dx.doi.org/10.3389/fchem.2022.867815 Text en Copyright © 2022 Chen, Hu, Zhang, Wu, Mao and Zheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Chen, Mantao
Hu, Chi
Zhang, Shengxiang
Wu, Dan
Mao, Zhengwei
Zheng, Xiujue
The Construction of Cucurbit[7]uril-Based Supramolecular Nanomedicine for Glioma Therapy
title The Construction of Cucurbit[7]uril-Based Supramolecular Nanomedicine for Glioma Therapy
title_full The Construction of Cucurbit[7]uril-Based Supramolecular Nanomedicine for Glioma Therapy
title_fullStr The Construction of Cucurbit[7]uril-Based Supramolecular Nanomedicine for Glioma Therapy
title_full_unstemmed The Construction of Cucurbit[7]uril-Based Supramolecular Nanomedicine for Glioma Therapy
title_short The Construction of Cucurbit[7]uril-Based Supramolecular Nanomedicine for Glioma Therapy
title_sort construction of cucurbit[7]uril-based supramolecular nanomedicine for glioma therapy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966231/
https://www.ncbi.nlm.nih.gov/pubmed/35372259
http://dx.doi.org/10.3389/fchem.2022.867815
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