Mechanical stress shapes the cancer cell response to neddylation inhibition

BACKGROUND: The inhibition of neddylation by the preclinical drug MLN4924 represents a new strategy to combat cancer. However, despite being effective against hematologic malignancies, its success in solid tumors, where cell–cell and cell-ECM interactions play essential roles, remains elusive. METHO...

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Detalles Bibliográficos
Autores principales: Mittler, Frédérique, Obeïd, Patricia, Haguet, Vincent, Allier, Cédric, Gerbaud, Sophie, Rulina, Anastasia V., Gidrol, Xavier, Balakirev, Maxim Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966269/
https://www.ncbi.nlm.nih.gov/pubmed/35354476
http://dx.doi.org/10.1186/s13046-022-02328-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966269/
https://www.ncbi.nlm.nih.gov/pubmed/35354476
http://dx.doi.org/10.1186/s13046-022-02328-y

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