Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer

BACKGROUND: The analysis of long non-coding RNA (lncRNA) in endometrial cancer is a novel field of science. Although numerous lncRNA sequences have been identified until today, their correlation with endometrial cancer is still undetermined. The aim of this study was to analyze the expression of fou...

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Autores principales: Bieńkiewicz, Jan, Romanowicz, Hanna, Szymańska, Bożena, Domańska-Senderowska, Daria, Wilczyński, Miłosz, Stepowicz, Anna, Malinowski, Andrzej, Smolarz, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966281/
https://www.ncbi.nlm.nih.gov/pubmed/35351056
http://dx.doi.org/10.1186/s12885-022-09426-2
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author Bieńkiewicz, Jan
Romanowicz, Hanna
Szymańska, Bożena
Domańska-Senderowska, Daria
Wilczyński, Miłosz
Stepowicz, Anna
Malinowski, Andrzej
Smolarz, Beata
author_facet Bieńkiewicz, Jan
Romanowicz, Hanna
Szymańska, Bożena
Domańska-Senderowska, Daria
Wilczyński, Miłosz
Stepowicz, Anna
Malinowski, Andrzej
Smolarz, Beata
author_sort Bieńkiewicz, Jan
collection PubMed
description BACKGROUND: The analysis of long non-coding RNA (lncRNA) in endometrial cancer is a novel field of science. Although numerous lncRNA sequences have been identified until today, their correlation with endometrial cancer is still undetermined. The aim of this study was to analyze the expression of four lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 and to investigate their significance in endometrial cancer. METHODS: LncRNA sequences were investigated in paraffin blocks (tumor tissue and non-malignant endometrial tissue in archival postoperative specimens) in endometrial cancer patients (Cases, n = 120) and in cancer-free controls (n = 80) using real-time PCR assay. RESULTS: This study revealed a lower expression of LINC01468 in endometrial cancer patients than in controls. Both LINC01468 and FAM3D-AS1 were positively correlated with Body Mass Index (BMI) in cancer-free controls. CONCLUSIONS: LncRNA LINC01468 may be a protective factor in development of endometrial cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-022-09426-2.
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spelling pubmed-89662812022-03-31 Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer Bieńkiewicz, Jan Romanowicz, Hanna Szymańska, Bożena Domańska-Senderowska, Daria Wilczyński, Miłosz Stepowicz, Anna Malinowski, Andrzej Smolarz, Beata BMC Cancer Research BACKGROUND: The analysis of long non-coding RNA (lncRNA) in endometrial cancer is a novel field of science. Although numerous lncRNA sequences have been identified until today, their correlation with endometrial cancer is still undetermined. The aim of this study was to analyze the expression of four lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 and to investigate their significance in endometrial cancer. METHODS: LncRNA sequences were investigated in paraffin blocks (tumor tissue and non-malignant endometrial tissue in archival postoperative specimens) in endometrial cancer patients (Cases, n = 120) and in cancer-free controls (n = 80) using real-time PCR assay. RESULTS: This study revealed a lower expression of LINC01468 in endometrial cancer patients than in controls. Both LINC01468 and FAM3D-AS1 were positively correlated with Body Mass Index (BMI) in cancer-free controls. CONCLUSIONS: LncRNA LINC01468 may be a protective factor in development of endometrial cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-022-09426-2. BioMed Central 2022-03-29 /pmc/articles/PMC8966281/ /pubmed/35351056 http://dx.doi.org/10.1186/s12885-022-09426-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Bieńkiewicz, Jan
Romanowicz, Hanna
Szymańska, Bożena
Domańska-Senderowska, Daria
Wilczyński, Miłosz
Stepowicz, Anna
Malinowski, Andrzej
Smolarz, Beata
Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer
title Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer
title_full Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer
title_fullStr Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer
title_full_unstemmed Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer
title_short Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer
title_sort analysis of lncrna sequences: fam3d-as1, linc01230, linc01315 and linc01468 in endometrial cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966281/
https://www.ncbi.nlm.nih.gov/pubmed/35351056
http://dx.doi.org/10.1186/s12885-022-09426-2
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