Cargando…

Evaluation of genetic variants using chromosomal microarray analysis for fetuses with polyhydramnios

BACKGROUND: Polyhydramnios, the excessive accumulation of amniotic fluid, is associated with an elevated risk of abnormal karyotype, particularly aneuploidy. Studies focusing on chromosomal microarray analysis (CMA) in pregnancies with polyhydramnios are limited. The aim of this study is to evaluate...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xiaoqing, Li, Ying, Lin, Na, Su, Linjuan, Xie, Xiaorui, Liang, Bing, Shen, Qingmei, Cai, Meiying, Guo, Danhua, Huang, Hailong, Xu, Liangpu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966299/
https://www.ncbi.nlm.nih.gov/pubmed/35354480
http://dx.doi.org/10.1186/s12920-022-01224-w
_version_ 1784678623992610816
author Wu, Xiaoqing
Li, Ying
Lin, Na
Su, Linjuan
Xie, Xiaorui
Liang, Bing
Shen, Qingmei
Cai, Meiying
Guo, Danhua
Huang, Hailong
Xu, Liangpu
author_facet Wu, Xiaoqing
Li, Ying
Lin, Na
Su, Linjuan
Xie, Xiaorui
Liang, Bing
Shen, Qingmei
Cai, Meiying
Guo, Danhua
Huang, Hailong
Xu, Liangpu
author_sort Wu, Xiaoqing
collection PubMed
description BACKGROUND: Polyhydramnios, the excessive accumulation of amniotic fluid, is associated with an elevated risk of abnormal karyotype, particularly aneuploidy. Studies focusing on chromosomal microarray analysis (CMA) in pregnancies with polyhydramnios are limited. The aim of this study is to evaluate the implications of pregnancy with polyhydramnios by CMA testing and routine karyotyping. METHODS: Data from 131 singleton and 17 twin pregnancies that underwent prenatal CMA testing due to polyhydramnios between May 2017 and May 2021 were reviewed. Enrolled cases were grouped into isolated polyhydramnios (N = 39) and non-isolated polyhydramnios (N = 111). Non-isolated group was further categorized as subgroup of soft markers (n = 59) and non-soft markers (n = 52). RESULTS: CMA revealed an additional 10 (6.7%) chromosomal aberrations with clinical significance in 9 fetuses from singleton pregnancies and 1 from a twin pregnancy. Six microdeletion/microduplication syndromes were observed, of which 4 were located on chromosome 17. The incremental yields of clinically significant CMA findings in non-isolated polyhydramnios was 8.1%, and the values in fetuses along with soft markers and non-soft markers were 5.1% and 11.5% (p > 0.05), respectively. Only one incidental finding related to neuropathy with liability to pressure palsies was detected from 39 fetuses with isolated polyhydramnios. CONCLUSIONS: Non-isolated polyhydramnios is associated with several microdeletion/microduplication syndromes, regardless of singleton or twin pregnancies. Our results suggest insufficient evidence to recommend CMA in pregnancies with isolated polyhydramnios. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-022-01224-w.
format Online
Article
Text
id pubmed-8966299
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-89662992022-03-31 Evaluation of genetic variants using chromosomal microarray analysis for fetuses with polyhydramnios Wu, Xiaoqing Li, Ying Lin, Na Su, Linjuan Xie, Xiaorui Liang, Bing Shen, Qingmei Cai, Meiying Guo, Danhua Huang, Hailong Xu, Liangpu BMC Med Genomics Research BACKGROUND: Polyhydramnios, the excessive accumulation of amniotic fluid, is associated with an elevated risk of abnormal karyotype, particularly aneuploidy. Studies focusing on chromosomal microarray analysis (CMA) in pregnancies with polyhydramnios are limited. The aim of this study is to evaluate the implications of pregnancy with polyhydramnios by CMA testing and routine karyotyping. METHODS: Data from 131 singleton and 17 twin pregnancies that underwent prenatal CMA testing due to polyhydramnios between May 2017 and May 2021 were reviewed. Enrolled cases were grouped into isolated polyhydramnios (N = 39) and non-isolated polyhydramnios (N = 111). Non-isolated group was further categorized as subgroup of soft markers (n = 59) and non-soft markers (n = 52). RESULTS: CMA revealed an additional 10 (6.7%) chromosomal aberrations with clinical significance in 9 fetuses from singleton pregnancies and 1 from a twin pregnancy. Six microdeletion/microduplication syndromes were observed, of which 4 were located on chromosome 17. The incremental yields of clinically significant CMA findings in non-isolated polyhydramnios was 8.1%, and the values in fetuses along with soft markers and non-soft markers were 5.1% and 11.5% (p > 0.05), respectively. Only one incidental finding related to neuropathy with liability to pressure palsies was detected from 39 fetuses with isolated polyhydramnios. CONCLUSIONS: Non-isolated polyhydramnios is associated with several microdeletion/microduplication syndromes, regardless of singleton or twin pregnancies. Our results suggest insufficient evidence to recommend CMA in pregnancies with isolated polyhydramnios. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-022-01224-w. BioMed Central 2022-03-30 /pmc/articles/PMC8966299/ /pubmed/35354480 http://dx.doi.org/10.1186/s12920-022-01224-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wu, Xiaoqing
Li, Ying
Lin, Na
Su, Linjuan
Xie, Xiaorui
Liang, Bing
Shen, Qingmei
Cai, Meiying
Guo, Danhua
Huang, Hailong
Xu, Liangpu
Evaluation of genetic variants using chromosomal microarray analysis for fetuses with polyhydramnios
title Evaluation of genetic variants using chromosomal microarray analysis for fetuses with polyhydramnios
title_full Evaluation of genetic variants using chromosomal microarray analysis for fetuses with polyhydramnios
title_fullStr Evaluation of genetic variants using chromosomal microarray analysis for fetuses with polyhydramnios
title_full_unstemmed Evaluation of genetic variants using chromosomal microarray analysis for fetuses with polyhydramnios
title_short Evaluation of genetic variants using chromosomal microarray analysis for fetuses with polyhydramnios
title_sort evaluation of genetic variants using chromosomal microarray analysis for fetuses with polyhydramnios
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966299/
https://www.ncbi.nlm.nih.gov/pubmed/35354480
http://dx.doi.org/10.1186/s12920-022-01224-w
work_keys_str_mv AT wuxiaoqing evaluationofgeneticvariantsusingchromosomalmicroarrayanalysisforfetuseswithpolyhydramnios
AT liying evaluationofgeneticvariantsusingchromosomalmicroarrayanalysisforfetuseswithpolyhydramnios
AT linna evaluationofgeneticvariantsusingchromosomalmicroarrayanalysisforfetuseswithpolyhydramnios
AT sulinjuan evaluationofgeneticvariantsusingchromosomalmicroarrayanalysisforfetuseswithpolyhydramnios
AT xiexiaorui evaluationofgeneticvariantsusingchromosomalmicroarrayanalysisforfetuseswithpolyhydramnios
AT liangbing evaluationofgeneticvariantsusingchromosomalmicroarrayanalysisforfetuseswithpolyhydramnios
AT shenqingmei evaluationofgeneticvariantsusingchromosomalmicroarrayanalysisforfetuseswithpolyhydramnios
AT caimeiying evaluationofgeneticvariantsusingchromosomalmicroarrayanalysisforfetuseswithpolyhydramnios
AT guodanhua evaluationofgeneticvariantsusingchromosomalmicroarrayanalysisforfetuseswithpolyhydramnios
AT huanghailong evaluationofgeneticvariantsusingchromosomalmicroarrayanalysisforfetuseswithpolyhydramnios
AT xuliangpu evaluationofgeneticvariantsusingchromosomalmicroarrayanalysisforfetuseswithpolyhydramnios