Cargando…

Targeting Neutrophils for Promoting the Resolution of Inflammation

Acute inflammation is a localized and self-limited innate host-defense mechanism against invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in humans, play pivotal roles in host defense by eradicating invading pathogens and debris. Ideally, elimination of the offending...

Descripción completa

Detalles Bibliográficos
Autor principal: Filep, János G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966391/
https://www.ncbi.nlm.nih.gov/pubmed/35371088
http://dx.doi.org/10.3389/fimmu.2022.866747
_version_ 1784678643543310336
author Filep, János G.
author_facet Filep, János G.
author_sort Filep, János G.
collection PubMed
description Acute inflammation is a localized and self-limited innate host-defense mechanism against invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in humans, play pivotal roles in host defense by eradicating invading pathogens and debris. Ideally, elimination of the offending insult prompts repair and return to homeostasis. However, the neutrophils` powerful weaponry to combat microbes can also cause tissue damage and neutrophil-driven inflammation is a unifying mechanism for many diseases. For timely resolution of inflammation, in addition to stopping neutrophil recruitment, emigrated neutrophils need to be disarmed and removed from the affected site. Accumulating evidence documents the phenotypic and functional versatility of neutrophils far beyond their antimicrobial functions. Hence, understanding the receptors that integrate opposing cues and checkpoints that determine the fate of neutrophils in inflamed tissues provides insight into the mechanisms that distinguish protective and dysregulated, excessive inflammation and govern resolution. This review aims to provide a brief overview and update with key points from recent advances on neutrophil heterogeneity, functional versatility and signaling, and discusses challenges and emerging therapeutic approaches that target neutrophils to enhance the resolution of inflammation.
format Online
Article
Text
id pubmed-8966391
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89663912022-03-31 Targeting Neutrophils for Promoting the Resolution of Inflammation Filep, János G. Front Immunol Immunology Acute inflammation is a localized and self-limited innate host-defense mechanism against invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in humans, play pivotal roles in host defense by eradicating invading pathogens and debris. Ideally, elimination of the offending insult prompts repair and return to homeostasis. However, the neutrophils` powerful weaponry to combat microbes can also cause tissue damage and neutrophil-driven inflammation is a unifying mechanism for many diseases. For timely resolution of inflammation, in addition to stopping neutrophil recruitment, emigrated neutrophils need to be disarmed and removed from the affected site. Accumulating evidence documents the phenotypic and functional versatility of neutrophils far beyond their antimicrobial functions. Hence, understanding the receptors that integrate opposing cues and checkpoints that determine the fate of neutrophils in inflamed tissues provides insight into the mechanisms that distinguish protective and dysregulated, excessive inflammation and govern resolution. This review aims to provide a brief overview and update with key points from recent advances on neutrophil heterogeneity, functional versatility and signaling, and discusses challenges and emerging therapeutic approaches that target neutrophils to enhance the resolution of inflammation. Frontiers Media S.A. 2022-03-16 /pmc/articles/PMC8966391/ /pubmed/35371088 http://dx.doi.org/10.3389/fimmu.2022.866747 Text en Copyright © 2022 Filep https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Filep, János G.
Targeting Neutrophils for Promoting the Resolution of Inflammation
title Targeting Neutrophils for Promoting the Resolution of Inflammation
title_full Targeting Neutrophils for Promoting the Resolution of Inflammation
title_fullStr Targeting Neutrophils for Promoting the Resolution of Inflammation
title_full_unstemmed Targeting Neutrophils for Promoting the Resolution of Inflammation
title_short Targeting Neutrophils for Promoting the Resolution of Inflammation
title_sort targeting neutrophils for promoting the resolution of inflammation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966391/
https://www.ncbi.nlm.nih.gov/pubmed/35371088
http://dx.doi.org/10.3389/fimmu.2022.866747
work_keys_str_mv AT filepjanosg targetingneutrophilsforpromotingtheresolutionofinflammation